Harsh Viraat, Jha Sukriti, Kumar Hitesh, Kumar Anil
a Neurosurgery , Rajendra Institute of Medical Sciences , Ranchi , Jharkhand , India.
Br J Neurosurg. 2019 Feb;33(1):58-61. doi: 10.1080/02688697.2018.1485875. Epub 2019 Jan 17.
Post-traumatic hypopituitarism has remained as an obscured cause of worsening morbidity and mortality in head injury patients. Researchers have for decades been puzzled by the mechanism of pituitary dysfunction in these cases. Amongst other causes like direct injury, vascular injury etc, an immunological basis of hypopituitarism has been suggested in some animal studies as well as human research. In this article, we have reviewed the latest articles and compiled the evidence which suggests for or against the role of autoimmunity in post-traumatic hypopituitarism or which defines the strength to which autoimmunity has been established as a cause of head-injury induced pituitary dysfunction.
创伤后垂体功能减退一直是颅脑损伤患者发病率和死亡率恶化的一个隐匿原因。几十年来，研究人员一直对这些病例中垂体功能障碍的机制感到困惑。在诸如直接损伤、血管损伤等其他原因中，一些动物研究以及人体研究均提示垂体功能减退存在免疫学基础。在本文中，我们回顾了最新的文章，并汇总了支持或反对自身免疫在创伤后垂体功能减退中作用的证据，或者明确自身免疫作为颅脑损伤所致垂体功能障碍病因的确立程度的证据。
