Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Groningen, The Netherlands.
Department of Neurology, Alzheimer Research Centre, University Medical Center Groningen, University of Groningen, Groningen, Groningen, The Netherlands.
PLoS One. 2019 Jan 17;14(1):e0211000. doi: 10.1371/journal.pone.0211000. eCollection 2019.
In Alzheimer's Disease (AD) dual-tracer positron emission tomography (PET) studies with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) and 11C-labelled Pittsburgh Compound B (PIB) are used to assess metabolism and cerebral amyloid-β deposition, respectively. Regional cerebral metabolism and blood flow (rCBF) are closely coupled, both providing an index for neuronal function. The present study compared PIB-derived rCBF, estimated by the ratio of tracer influx in target regions relative to reference region (R1) and early-stage PIB uptake (ePIB), to FDG scans. Fifteen PIB positive (+) patients and fifteen PIB negative (-) subjects underwent both FDG and PIB PET scans to assess the use of R1 and ePIB as a surrogate for FDG. First, subjects were classified based on visual inspection of the PIB PET images. Then, discriminative performance (PIB+ versus PIB-) of rCBF methods were compared to normalized regional FDG uptake. Strong positive correlations were found between analyses, suggesting that PIB-derived rCBF provides information that is closely related to what can be seen on FDG scans. Yet group related differences between method's distributions were seen as well. Also, a better correlation with FDG was found for R1 than for ePIB. Further studies are needed to validate the use of R1 as an alternative for FDG studies in clinical applications.
在阿尔茨海默病（AD）的双示踪正电子发射断层扫描（PET）研究中，2-[18F]-氟-2-脱氧-D-葡萄糖（FDG）和 11C 标记的匹兹堡化合物 B（PIB）分别用于评估代谢和脑淀粉样蛋白-β沉积。局部脑代谢和血流（rCBF）密切相关，两者均为神经元功能的指标。本研究比较了 PIB 衍生的 rCBF，通过目标区域与参考区域（R1）之间示踪剂流入的比率以及早期 PIB 摄取（ePIB）来估计，与 FDG 扫描。15 名 PIB 阳性（+）患者和 15 名 PIB 阴性（-）受试者均接受了 FDG 和 PIB PET 扫描，以评估 R1 和 ePIB 作为 FDG 的替代物的使用。首先，根据 PIB PET 图像的视觉检查对受试者进行分类。然后，比较 rCBF 方法的判别性能（PIB+与 PIB-）与标准化区域 FDG 摄取。分析之间存在强烈的正相关，表明 PIB 衍生的 rCBF 提供了与 FDG 扫描所见密切相关的信息。然而，也观察到了方法分布之间的组相关差异。此外，R1 与 FDG 的相关性优于 ePIB。需要进一步的研究来验证 R1 在临床应用中替代 FDG 研究的用途。
