Semaphorins 在免疫病理学和风湿性疾病中的作用。
Role of Semaphorins in Immunopathologies and Rheumatic Diseases.
机构信息
Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
出版信息
Int J Mol Sci. 2019 Jan 16;20(2):374. doi: 10.3390/ijms20020374.
Rheumatic diseases are disorders characterized by joint inflammation, in which other organs are also affected. There are more than two hundred rheumatic diseases, the most studied so far are rheumatoid arthritis, osteoarthritis, spondyloarthritis, systemic lupus erythematosus, and systemic sclerosis. The semaphorin family is a large group of proteins initially described as axon guidance molecules involved in nervous system development. Studies have demonstrated that semaphorins play a role in other processes such as the regulation of immunity, angiogenesis, bone remodeling, apoptosis, and cell migration and invasion. Moreover, semaphorins have been related to the pathogenesis of multiple sclerosis, asthma, Alzheimer, myocarditis, atherosclerosis, fibrotic diseases, osteopetrosis, and cancer. The aim of this review is to summarize current knowledge regarding the role of semaphorins in rheumatic diseases, and discuss their potential applications as therapeutic targets to treat these disorders.
风湿性疾病是以关节炎症为特征的疾病，其中其他器官也会受到影响。有超过 200 种风湿性疾病，目前研究最多的是类风湿关节炎、骨关节炎、脊柱关节炎、系统性红斑狼疮和系统性硬化症。信号蛋白家族是一大组蛋白，最初被描述为参与神经系统发育的轴突导向分子。研究表明，信号蛋白在免疫调节、血管生成、骨重塑、细胞凋亡和细胞迁移和侵袭等其他过程中发挥作用。此外，信号蛋白与多发性硬化症、哮喘、阿尔茨海默病、心肌炎、动脉粥样硬化、纤维化疾病、骨质疏松症和癌症的发病机制有关。本综述的目的是总结信号蛋白在风湿性疾病中的作用的现有知识，并讨论它们作为治疗靶点治疗这些疾病的潜在应用。
Zotero 插件