Molina Francisco, Del Moral María Luisa, La Rubia Mercedes, Blanco Santos, Carmona Ramón, Rus Alma
1 Department of Health Science, University of Jaén, Jaén, Spain.
2 Department of Experimental Biology, University of Jaén, Jaén, Spain.
Biol Res Nurs. 2019 Mar;21(2):224-230. doi: 10.1177/1099800418824716. Epub 2019 Jan 17.
The aim of this study was to investigate thrombosis-related parameters (blood coagulation parameters, platelet indices, red blood cell [RBC] count, and inflammatory markers) in patients with fibromyalgia (FM).
We carried out a case-control study with 35 women with FM and 12 age-matched healthy volunteers to analyze fibrinogen levels, prothrombin time, cephaline time, platelet count, platelet distribution width (PDW), mean platelet volume (MPV), RBC count, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio (PLR).
The results showed significantly increased fibrinogen levels ( p < .05), platelet count ( p < .05), PDW ( p = .059), RBC count ( p < .05), and PLR ( p < .05) in women with FM versus the healthy volunteers. Prothrombin time ( p < .05) and MPV ( p < .05) were significantly lower in patients with FM than in the controls.
Elevated platelet and RBC counts, PDW values, and fibrinogen levels as well as decreased prothrombin time are all indicative of a prothrombotic state in FM patients, which may be enhanced by an increased inflammatory tone. This prothrombotic state may increase the risk of thrombosis-related cardiovascular disease in patients with FM.
本研究旨在调查纤维肌痛（FM）患者的血栓形成相关参数（凝血参数、血小板指标、红细胞[RBC]计数和炎症标志物）。
我们进行了一项病例对照研究，纳入35名FM女性患者和12名年龄匹配的健康志愿者，分析纤维蛋白原水平、凝血酶原时间、脑磷脂时间、血小板计数、血小板分布宽度（PDW）、平均血小板体积（MPV）、RBC计数、中性粒细胞与淋巴细胞比值以及血小板与淋巴细胞比值（PLR）。
结果显示，与健康志愿者相比，FM女性患者的纤维蛋白原水平（p <.05）、血小板计数（p <.05）、PDW（p =.059）、RBC计数（p <.05）和PLR（p <.05）显著升高。FM患者的凝血酶原时间（p <.05）和MPV（p <.05）显著低于对照组。
血小板和RBC计数升高、PDW值以及纤维蛋白原水平升高，以及凝血酶原时间降低均表明FM患者存在血栓前状态，炎症状态增加可能会加剧这种情况。这种血栓前状态可能会增加FM患者发生血栓相关心血管疾病的风险。
