脂肪酶催化合成（R）-2-苄氧基-2-异丙基氢丙二酸乙酯：化学合成与酶法的有效结合
Lipase-catalyzed synthesis of ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods.
作者信息
Ding Jing, Yang Zhijun, Zhao Yu, Fang Weizhen, Lu Qun
机构信息
a Department of Chemistry, School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China.
b Yunnan Provincial Key Laboratory of Medical Insects and Spiders Resources for Development and Utilization , Dali University , Dali , China.
出版信息
Biosci Biotechnol Biochem. 2019 Apr;83(4):763-767. doi: 10.1080/09168451.2018.1554426. Epub 2019 Jan 17.
Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester.
（R）-2-苄氧基-2-异丙基丙二酸乙酯是麦角肽类药物侧链合成的关键中间体。在本研究中，我们采用了一种方法，通过固定化南极假丝酵母脂肪酶B（诺维信435）催化相应的二酯水解来制备对映体纯的标题单酯。
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