Center for One Health Research, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, MG, Brazil.
Vaccine. 2019 Feb 8;37(7):910-914. doi: 10.1016/j.vaccine.2018.12.070. Epub 2019 Jan 14.
Feral swine cost around $1.5 billion each year in agricultural, environmental, and personal property damages. They are also the most widespread carriers of the zoonotic disease brucellosis, which threatens both livestock bio-security and public health. Currently, there is no approved vaccine against brucellosis in pigs. This is a preliminary report on the development of a live-attenuated B. suis vaccine that could be employed to deliver heterologous antigens to control swine populations. An attenuated vaccine strain provided significant protection against B. suis challenge in mice. Leucine auxotrophy in the vaccine strain allowed the over-expression of heterologous antigens without the use of antibiotic resistant markers. Vaccinated mice showed the development of antibodies against expressed antigen. Further evaluation is required to assess its ability to cause infertility using the mouse model prior to further testing for use as a tool for feral swine population and disease control.
野猪每年给农业、环境和个人财产造成约 15 亿美元的损失。它们也是最广泛传播人畜共患布鲁氏菌病的携带者，这威胁着牲畜的生物安全和公共卫生。目前，尚无批准用于猪的布鲁氏菌病疫苗。这是一份关于开发减毒猪布鲁氏菌活疫苗的初步报告，该疫苗可用于携带异源抗原来控制猪群。减毒疫苗株在小鼠中对布鲁氏菌的攻击提供了显著的保护。疫苗株中的亮氨酸营养缺陷允许在不使用抗生素抗性标记的情况下过表达异源抗原。接种疫苗的小鼠显示出针对表达抗原的抗体的发展。需要进一步评估其在进一步测试作为控制野猪种群和疾病的工具之前，在小鼠模型中引起不育的能力。
