Ueda Naoko, Fujita Kohei, Okuno Yoshiaki, Nakatani Koichi, Mio Tadashi
Division of Respiratory Medicine, Center for Respiratory Diseases National Hospital Organization Kyoto Medical Center Kyoto Japan.
Department of Nephrology National Hospital Organization Kyoto Medical Center Kyoto Japan.
Clin Case Rep. 2018 Nov 19;7(1):100-103. doi: 10.1002/ccr3.1931. eCollection 2019 Jan.
We experienced therapy-related acute myeloid leukemia (t-AML) in a patient with extensive disease-small cell lung cancer (ED-SCLC). This case is rare and has educational message because ED-SCLC has a poor prognosis and often cannot survive until developing therapy related hematological malignancy. Furthermore this case had unique chromosomal abnormalities. With recent advances in chemotherapy and radiotherapy, the prognosis of lung cancer has improved, while t-AML has been increasing in frequency.
我们在一名患有广泛期疾病——小细胞肺癌（ED-SCLC）的患者中遇到了治疗相关的急性髓系白血病（t-AML）。该病例较为罕见且具有教育意义，因为ED-SCLC预后较差，通常在发展为治疗相关血液系统恶性肿瘤之前就无法存活。此外，该病例存在独特的染色体异常。随着化疗和放疗的最新进展，肺癌的预后有所改善，而t-AML的发生率却在增加。
