Helios-controller of Treg stability and function.
作者信息
Chougnet Claire, Hildeman David
机构信息
Division of Immunobiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, OH 45229, USA.
出版信息
Transl Cancer Res. 2016 Aug;5(Suppl 2):S338-S341. doi: 10.21037/tcr.2016.07.37.
Abstract
摘要
相似文献
1
Helios-controller of Treg stability and function.Helios——调节性T细胞稳定性和功能的调控因子
Transl Cancer Res. 2016 Aug;5(Suppl 2):S338-S341. doi: 10.21037/tcr.2016.07.37.
2
Helios Enhances Treg Cell Function in Cooperation With FoxP3.海利奥斯与 FoxP3 共同增强调节性 T 细胞的功能。
Arthritis Rheumatol. 2015 Jun;67(6):1491-502. doi: 10.1002/art.39091.
3
Foxp3Helios regulatory T cells are associated with monocyte subsets and their PD-1 expression during acute HIV-1 infection.Foxp3Helios 调节性 T 细胞与急性 HIV-1 感染期间单核细胞亚群及其 PD-1 表达有关。
BMC Immunol. 2019 Oct 24;20(1):38. doi: 10.1186/s12865-019-0319-7.
4
Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus.Foxp3+Helios+调节性 T 细胞在活动性系统性红斑狼疮中扩增。
Ann Rheum Dis. 2013 Sep 1;72(9):1549-58. doi: 10.1136/annrheumdis-2012-202216. Epub 2012 Dec 21.
5
IFNγ+ Treg in-vivo and in-vitro represent both activated nTreg and peripherally induced aTreg and remain phenotypically stable in-vitro after removal of the stimulus.体内和体外的IFNγ+调节性T细胞均代表活化的天然调节性T细胞和外周诱导的适应性调节性T细胞，并且在去除刺激后在体外保持表型稳定。
BMC Immunol. 2015 Aug 13;16:45. doi: 10.1186/s12865-015-0111-2.
6
Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.TIGIT和FCRL3的共表达可识别出Helios+人类记忆调节性T细胞。
J Immunol. 2015 Apr 15;194(8):3687-96. doi: 10.4049/jimmunol.1401803. Epub 2015 Mar 11.
7
Helios Controls a Limited Subset of Regulatory T Cell Functions.太阳神控制调节性T细胞功能的有限子集。
J Immunol. 2016 Jan 1;196(1):144-55. doi: 10.4049/jimmunol.1501704. Epub 2015 Nov 18.
8
Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content.在胎儿染色体含量正常的流产病例蜕膜中，Helios阳性功能性调节性T细胞减少。
J Reprod Immunol. 2015 Feb;107:10-9. doi: 10.1016/j.jri.2014.09.053. Epub 2014 Oct 17.
9
Helios expression and Foxp3 TSDR methylation of IFNy+ and IFNy- Treg from kidney transplant recipients with good long-term graft function.具有良好长期移植肾功能的肾移植受者中IFNy+和IFNy-调节性T细胞的Helios表达及Foxp3调节性T细胞脱甲基区域甲基化情况
PLoS One. 2017 Mar 15;12(3):e0173773. doi: 10.1371/journal.pone.0173773. eCollection 2017.
10
Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice.联合分析Helios和神经纤毛蛋白-1作为检测未成熟小鼠胸腺来源调节性T细胞的标志物。
Sci Rep. 2015 Jan 14;5:7767. doi: 10.1038/srep07767.
引用本文的文献
1
Interferon-β and interleukin-6 exert opposing effects on Foxp3 acetylation to control regulatory T cell induction.干扰素-β和白细胞介素-6对Foxp3乙酰化发挥相反作用，以控制调节性T细胞的诱导。
Front Immunol. 2025 May 30;16:1593931. doi: 10.3389/fimmu.2025.1593931. eCollection 2025.
2
Osteopontin Regulates Treg Cell Stability and Function with Implications for Anti-Tumor Immunity and Autoimmunity.骨桥蛋白调节调节性T细胞的稳定性和功能，对抗肿瘤免疫和自身免疫具有重要意义。
Cancers (Basel). 2024 Aug 24;16(17):2952. doi: 10.3390/cancers16172952.
3
Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients.诱导FoxP3前体信使核糖核酸可变剪接以增强肌萎缩侧索硬化症患者调节性T细胞的抑制活性
Biomedicines. 2024 May 7;12(5):1022. doi: 10.3390/biomedicines12051022.
4
Single cell characterization of blood and expanded regulatory T cells in autoimmune polyendocrine syndrome type 1.1型自身免疫性多内分泌综合征中血液和扩增调节性T细胞的单细胞特征分析
iScience. 2024 Mar 27;27(4):109610. doi: 10.1016/j.isci.2024.109610. eCollection 2024 Apr 19.
5
Th17/1 and ex-Th17 cells are detected in patients with polyarticular juvenile arthritis and increase following treatment.在多关节型幼年特发性关节炎患者中可检测到Th17/1细胞和既往Th17细胞，且在治疗后数量增加。
Pediatr Rheumatol Online J. 2024 Mar 2;22(1):32. doi: 10.1186/s12969-024-00965-5.
6
A disrupted FOXP3 transcriptional signature underpins systemic regulatory T cell insufficiency in early pregnancy failure.FOXP3转录特征的破坏是早期妊娠失败中系统性调节性T细胞功能不全的基础。
iScience. 2024 Jan 23;27(2):108994. doi: 10.1016/j.isci.2024.108994. eCollection 2024 Feb 16.
7
Regulatory T cells in spondyloarthropathies: genetic evidence, functional role, and therapeutic possibilities.脊柱关节炎中调节性 T 细胞：遗传证据、功能作用和治疗可能性。
Front Immunol. 2024 Jan 15;14:1303640. doi: 10.3389/fimmu.2023.1303640. eCollection 2023.
8
Treg in inborn errors of immunity: gaps, knowns and future perspectives.固有免疫缺陷中的调节性 T 细胞：差距、已知和未来展望。
Front Immunol. 2024 Jan 8;14:1278759. doi: 10.3389/fimmu.2023.1278759. eCollection 2023.
9
Selective ablation of thymic and peripheral Foxp3 regulatory T cell development.选择性消融胸腺和外周 Foxp3 调节性 T 细胞发育。
Front Immunol. 2023 Dec 18;14:1298938. doi: 10.3389/fimmu.2023.1298938. eCollection 2023.
10
Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case-control study.转录因子 Helios 定义的调节性 T 细胞亚群在卒中中的时变及其在卒中相关感染中的潜在作用：一项前瞻性病例对照研究。
J Neuroinflammation. 2023 Nov 23;20(1):275. doi: 10.1186/s12974-023-02957-w.
本文引用的文献
1
Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity.缺乏Helios的调节性T细胞的不稳定性与向效应性T细胞表型的转变及增强的抗肿瘤免疫相关。
Proc Natl Acad Sci U S A. 2016 May 31;113(22):6248-53. doi: 10.1073/pnas.1604765113. Epub 2016 May 16.
2
Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque.脂多糖诱导的绒毛膜羊膜炎促进恒河猴胎儿中白细胞介素-1依赖性炎性FOXP3 + CD4 + T细胞的生成。
J Immunol. 2016 May 1;196(9):3706-15. doi: 10.4049/jimmunol.1502613. Epub 2016 Apr 1.
3
Helios Controls a Limited Subset of Regulatory T Cell Functions.太阳神控制调节性T细胞功能的有限子集。
J Immunol. 2016 Jan 1;196(1):144-55. doi: 10.4049/jimmunol.1501704. Epub 2015 Nov 18.
4
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.调节性T细胞的稳定抑制活性需要转录因子Helios。
Science. 2015 Oct 16;350(6258):334-9. doi: 10.1126/science.aad0616.
5
IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age.白细胞介素-6和诱导共刺激分子随年龄增长拮抗Bim并促进调节性T细胞积累。
J Immunol. 2015 Aug 1;195(3):944-52. doi: 10.4049/jimmunol.1500443. Epub 2015 Jun 24.
6
IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels.IL-15 促进了衰老过程中调节性 T 细胞的积累，尽管 IL-2 水平下降。
Front Immunol. 2013 Jun 24;4:161. doi: 10.3389/fimmu.2013.00161. eCollection 2013.
7
Comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans".对“人类天然FOXP3 + T调节性细胞亚群中存在Helios +和Helios-细胞共存”的评论
J Immunol. 2013 May 1;190(9):4439-40. doi: 10.4049/jimmunol.1390018.
8
Regulatory T cells: recommendations to simplify the nomenclature.调节性T细胞：简化命名法的建议。
Nat Immunol. 2013 Apr;14(4):307-8. doi: 10.1038/ni.2554.
9
Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.人类天然 FOXP3+T 调节性细胞亚群中存在 Helios+和 Helios-细胞。
J Immunol. 2013 Mar 1;190(5):2001-8. doi: 10.4049/jimmunol.1201379. Epub 2013 Jan 28.
10
Helios expression is a marker of T cell activation and proliferation.Helios 表达是 T 细胞活化和增殖的标志物。
PLoS One. 2011;6(8):e24226. doi: 10.1371/journal.pone.0024226. Epub 2011 Aug 30.
Zotero 插件