Wahn V
Universitäts-Kinderklinik Düsseldorf.
Monatsschr Kinderheilkd. 1988 Aug;136(8):414-29.
As the numbers of children suffering from AIDS are slowly increasing in West Germany it is essential for pediatricians to be aware of events leading to clinically overt disease. This review summarizes events involved in viral attachment to CD4-bearing cells, intracellular replication, and destruction of both HIV-infected and non-infected cells. As a consequence of HIV-infection a profound and complex immunodeficiency is observed which is only partially explained by the loss of circulating CD4-bearing cells. Functions of antibodies, cytotoxic T-cells, natural killer cells, killer cells, as well as non-specific immune functions are discussed not only with respect to defense mechanisms in general but also with respect to the control of HIV-infection itself. Detailed understanding of these events seems to be a prerequisite for understanding the occurrence of infections and tumours in AIDS.
由于在西德感染艾滋病的儿童数量正缓慢增加，儿科医生必须了解导致临床显性疾病的相关情况。本综述总结了病毒附着于携带CD4的细胞、细胞内复制以及HIV感染细胞和未感染细胞破坏过程中涉及的相关情况。HIV感染会导致严重且复杂的免疫缺陷，循环中携带CD4的细胞减少只是部分原因。不仅从一般防御机制方面，而且从对HIV感染本身的控制方面，讨论了抗体、细胞毒性T细胞、自然杀伤细胞、杀伤细胞以及非特异性免疫功能。详细了解这些情况似乎是理解艾滋病患者感染和肿瘤发生的先决条件。
