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[辐射诱导突变剂量反应关系线性的新结果]

[New results on the linearity of the dose-response relationship of radiation-induced mutation].

作者信息

Traut H

机构信息

Institut für Strahlenbiologie der Universität, Münster.

出版信息

Naturwissenschaften. 1988 Aug;75(8):375-9. doi: 10.1007/BF00377813.

Abstract

Mutations induced by ionizing radiation in germ cells may affect future generations; mutations induced in somatic cells may damage the irradiated persons themselves, because radiation carcinogenesis is assumed to result from genetic damage induced in somatic cells. Since we are exposed mainly to low doses of ionizing radiation, both from natural and artificial sources, especially the dose dependence of radiation-induced mutations in the low-dose range is of interest. A review of recent studies on the induction of mutations by X-rays in human cells (in vitro) favors the hypothesis that in the low-dose range the dose dependence is linear, without a "threshold."

摘要

生殖细胞中由电离辐射诱发的突变可能会影响后代;体细胞中诱发的突变可能会损害受辐射者自身,因为辐射致癌被认为是由体细胞中的基因损伤所致。由于我们主要受到来自天然和人工来源的低剂量电离辐射照射,尤其是低剂量范围内辐射诱发突变的剂量依赖性备受关注。一项关于X射线在人体细胞(体外)中诱发突变的近期研究综述支持了这样一种假说,即在低剂量范围内剂量依赖性是线性的,不存在“阈值”。

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