老年胶质母细胞瘤患者的合并症：一项现场实践研究。
Comorbidities in elderly patients with glioblastoma: a field-practice study.
机构信息
Neuro-Oncology Unit, 'Regina Elena' National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Division of Neurosurgery, 'Regina Elena' National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
出版信息
Future Oncol. 2019 Mar;15(8):841-850. doi: 10.2217/fon-2018-0524. Epub 2019 Jan 18.
AIM
This single-center study evaluated the effect of comorbidities on progression-free and overall survival in elderly patients with glioblastoma multiforme (GBM).
PATIENTS & METHODS: Comorbid conditions were identified in each patient with the modified version of the cumulative illness rating scale (CIRS).
RESULTS
Total of 118 patients with GBM were enrolled. An age of >75 years at diagnosis, high CIRS, comorbidity index and performance status play a predictive role on survival.
CONCLUSION
Comorbidities play an important prognostic role in elderly patients with GBM, a factor too often neglected in clinical practice. If the prognostic role of comorbidity measured by CIRS on outcome will be confirmed, it would be interesting to add it in the algorithm for treatment choice in elderly GBM patients.
目的
本单中心研究评估了合并症对老年多形性胶质母细胞瘤（GBM）患者无进展生存期和总生存期的影响。
患者与方法
每位患者的合并症情况均采用改良累积疾病评分量表（CIRS）进行评估。
结果
共纳入 118 例 GBM 患者。诊断时年龄＞75 岁、高 CIRS、合并症指数和功能状态对生存具有预测作用。
结论
合并症在老年 GBM 患者的预后中起着重要作用，但在临床实践中往往被忽视。如果 CIRS 评估的合并症的预后作用在结果上得到证实，那么在老年 GBM 患者的治疗选择算法中加入这一因素将是有趣的。
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