Neurological Department, ASST Lecco, Via Dell' Eremo 9-11, 23900 Lecco, Italy.
Neurological Department, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore 3, 20162 Milano, Italy.
J Neurol Sci. 2019 May 15;400:175-179. doi: 10.1016/j.jns.2019.04.002. Epub 2019 Apr 3.
Preoperative prognostic nutritional index (PNI) is linked to the clinical outcome of patients with malignant tumours, however few studies have investigated its utility in predicting outcome in glioblastoma multiforme (GBM). We performed a retrospective study on adult patients with GBM in order to evaluate the impact of PNI on overall survival (OS), after adjusting for known prognostic factor (age, extent of surgery, Karnofsky performance status, radiochemotherapy). This is an Italian, multicentre, retrospective, cohort study. The patient's cohort includes 282 individuals with a newly diagnosed GBM followed in 3 Lombardia Hospitals In all cases the diagnosis was supported by histological data. Patient's information including sex, age at onset, Karnofsky performance status (KPS), extension of surgical resection (EOR), adjuvant treatment, antiepileptic treatment, serum variables and survival data were collected. Univariate and multivariate analysis did not reveal an association between PNI and overall survival in our series of GBM patients. PNI is a controversial marker for prognosis in GBM patients and further prospective studies are necessary to elucidate its role.
术前预后营养指数（PNI）与恶性肿瘤患者的临床结局相关，但很少有研究探讨其在预测多形性胶质母细胞瘤（GBM）患者结局方面的作用。我们对成人 GBM 患者进行了一项回顾性研究，以评估 PNI 在调整已知预后因素（年龄、手术范围、卡诺夫斯基表现状态、放化疗）后对总生存期（OS）的影响。这是一项意大利多中心回顾性队列研究。患者队列包括在 3 家伦巴第医院接受新诊断 GBM 治疗的 282 名患者。所有病例均通过组织学数据得到确诊。收集了患者的信息，包括性别、发病年龄、卡诺夫斯基表现状态（KPS）、手术切除范围（EOR）、辅助治疗、抗癫痫治疗、血清学指标和生存数据。单因素和多因素分析均未显示 PNI 与我们系列 GBM 患者的总体生存率之间存在关联。PNI 是 GBM 患者预后的一个有争议的标志物，需要进一步的前瞻性研究来阐明其作用。
