用于制备 N-芳基-氧杂环丁胺的水 N-芳基化氧杂环丁胺；潜在有用的芳基酰胺等排体。
On water N-arylation of oxetanylamines for the preparation of N-aryl-oxetanylamines; potentially useful aryl-amide isosteres.
机构信息
Laboratoire d'Innovation Thérapeutique, University of Strasbourg, 74 route du Rhin, BP60024, 67401 Illkirch, France.
出版信息
Chem Commun (Camb). 2019 Jan 31;55(11):1623-1626. doi: 10.1039/c8cc09110b.
PMID:30657138
Abstract
A Pd cross-coupling approach for the synthesis of N-aryl-oxetanylamines has been developed. This method provides new building blocks potentially useful in medicinal chemistry as amide bioisosteres. The reactions are conducted in water employing the renewable feedstock surfactant TPGS-750-M.
摘要
发展了一种 Pd 交叉偶联方法来合成 N-芳基-氧杂环丁烷胺。该方法提供了在药物化学中作为酰胺生物等排体可能有用的新砌块。反应在水中进行，使用可再生原料表面活性剂 TPGS-750-M。
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