Division of Orthodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan.
Graduate Institute of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
Orthod Craniofac Res. 2019 May;22(2):112-117. doi: 10.1111/ocr.12290. Epub 2019 Feb 5.
To evaluate the effect of botulinum toxin type A (BTX)-induced masticatory muscle hypofunction on the maxillofacial suture bone growth of growing rats.
Department of Orthodontics at Taipei Medical University. Forty-eight male 4-week-old Wistar rats were divided into four groups. The N group received injections of normal saline into each of the masseter and temporalis muscles. The M group received injections of normal saline into each of the temporalis muscle and injections of BTX into each of the masseter muscle. The T group received injections of normal saline into each of the masseter muscle and injections of BTX into each of the temporalis muscle. The MT group received injections of BTX into each of the masseter and temporalis muscles.
MATERIAL & METHODS: Rats were sacrificed after 42 days of growth. Changes in body and muscle weight were measured. Anthropometric measurements of the maxillary arch, sutural bone mineral density and sutural bone deposition distances were recorded. Statistical comparisons were performed using analysis of variance.
No significant change in body weight was found across groups. However, significant decreases were observed in muscle weight, anthropometric measurements, sutural bone mineral density and bone apposition distance in the BTX-injected group.
Reduced masticatory muscle function in growing rats can affect maxillofacial suture bone growth.
评估肉毒毒素 A（BTX）诱导的咀嚼肌功能减退对生长大鼠颌面部缝骨生长的影响。
台北医学大学正畸科。48 只 4 周龄雄性 Wistar 大鼠分为 4 组。N 组向每块咬肌和颞肌注射生理盐水。M 组向每块颞肌注射生理盐水，向每块咬肌注射 BTX。T 组向每块咬肌注射生理盐水，向每块颞肌注射 BTX。MT 组向每块咬肌和颞肌注射 BTX。
生长 42 天后处死大鼠。测量体重和肌肉重量的变化。记录上颌弓、缝骨矿物质密度和缝骨沉积距离的人体测量学测量值。使用方差分析进行统计学比较。
各组体重无显著变化。然而，在 BTX 注射组中，肌肉重量、人体测量学测量值、缝骨矿物质密度和骨形成距离均显著降低。
生长大鼠咀嚼肌功能减退可影响颌面部缝骨生长。
