Department of Oncology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, China.
Eur Rev Med Pharmacol Sci. 2019 Jan;23(1):181-186. doi: 10.26355/eurrev_201901_16763.
Previous study has reported that long noncoding RNA AK001796 (AK001796) functions as a tumor promoter in esophageal squamous cell carcinoma (ESCC). However, its clinical in ESCC patients remains largely unclear. The purpose of the present study was to evaluate the prognostic value of AK001796 in ESCC patients.
The expression levels of AK001796 in ESCC tissues and matched normal tissues were detected by RT-PCR. Association between AK001796 levels and clinicopathological factors was also analyzed by chi-square test. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan-Meier method and log-rank test. The predictors for OS and DFS were assessed by univariate analysis and multivariate analysis using Cox's proportional hazards model.
We found that AK001796 was elevated in human ESCC samples compared with the adjacent normal tissues (p<0.01), and the high level of AK001796 expression was significantly correlated with lymph node metastasis (p=0.032) and advanced UICC stage (p=0.016). Interestingly, Kaplan-Meier analysis indicated that patients with high AK001796 expression had a significantly lower OS (p=0.010) and DFS (p=0.001). Moreover, we showed that AK001796 was an independent poor prognostic factor for OS and DFS in ESCC patients through univariate and multivariate analysis.
Our data provide important evidence that AK001796 may be a useful biomarker of advanced progression and poor prognosis of ESCC.
先前的研究报告表明，长非编码 RNA AK001796（AK001796）在食管鳞状细胞癌（ESCC）中作为肿瘤促进物发挥作用。然而，其在 ESCC 患者中的临床应用仍存在很大的不确定性。本研究旨在评估 AK001796 在 ESCC 患者中的预后价值。
通过 RT-PCR 检测 ESCC 组织和配对正常组织中 AK001796 的表达水平。通过卡方检验分析 AK001796 水平与临床病理因素的相关性。采用 Kaplan-Meier 法和对数秩检验分析总生存期（OS）和无病生存期（DFS）。采用单因素和多因素 Cox 比例风险模型分析 OS 和 DFS 的预测因素。
我们发现，与相邻正常组织相比，AK001796 在人类 ESCC 样本中上调（p<0.01），AK001796 的高水平表达与淋巴结转移（p=0.032）和 UICC 晚期分期（p=0.016）显著相关。有趣的是，Kaplan-Meier 分析表明，AK001796 高表达的患者 OS（p=0.010）和 DFS（p=0.001）显著降低。此外，我们通过单因素和多因素分析表明，AK001796 是 ESCC 患者 OS 和 DFS 的独立不良预后因素。
我们的数据提供了重要证据，表明 AK001796 可能是 ESCC 进展和预后不良的有用生物标志物。
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