Sujka Monika, Pankiewicz Urszula, Kowalski Radosław, Nowosad Karolina, Noszczyk-Nowak Agnieszka
Department of Analysis and Evaluation of Food Quality, University of Life Sciences in Lublin, Poland.
Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wrocław University of Environmental and Life Sciences, Poland.
Polim Med. 2018 Jan-Jun;48(1):25-29. doi: 10.17219/pim/99799.
In recent years, starch has become a new potential biomaterial for pharmaceutical applications. This biopolymer has unique physicochemical and functional characteristics, as well as various advantages such as low price, relative ease of isolation in pure form from the plant source, non-toxicity, biodegradability, good biocompatibility, and interaction with living cells. Starch is currently used in pharmacy as a binder, disintegrating agent, film-forming material, raw material for production of microspheres and nanoparticles, and a component of drug delivery systems. Porous starch, which can be obtained with physical, chemical and enzymatic methods of modification, has a large specific surface area thanks to the presence of pores and channels. It has excellent adsorption capacity and can be used to enhance the dissolution rate of poorly soluble drugs or as shell material to improve the stability and water-solubility of compounds. As a component of drug delivery systems, porous starch has another advantage: it is biodegradable, so there is no need to remove it from the body after the release of the active agent.
近年来，淀粉已成为一种用于制药应用的新型潜在生物材料。这种生物聚合物具有独特的物理化学和功能特性，以及各种优点，如价格低廉、相对易于从植物来源中以纯形式分离、无毒、可生物降解、良好的生物相容性以及与活细胞相互作用。淀粉目前在制药中用作粘合剂、崩解剂、成膜材料、微球和纳米颗粒生产的原料以及药物递送系统的组成部分。通过物理、化学和酶促改性方法可获得的多孔淀粉，由于存在孔隙和通道，具有较大的比表面积。它具有优异的吸附能力，可用于提高难溶性药物的溶解速率，或用作壳材料以提高化合物的稳定性和水溶性。作为药物递送系统的组成部分，多孔淀粉还有另一个优点：它是可生物降解的，因此在活性剂释放后无需从体内去除。
