Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Haidian 100850, PR China.
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Haidian 100850, PR China.
Int J Biol Macromol. 2018 Sep;116:707-714. doi: 10.1016/j.ijbiomac.2018.05.059. Epub 2018 May 12.
Porous starch (PS) is a multifunctional biomaterial and has been widely applied in both pharmaceutical and food industry. This study was carried out to develop a new type of porous starch microspheres (PSM) through the dual-modification of the alcohol-alkaline treatment and inverse crosslinking-emulsion method, which could rapidly uptake water. The chemical and physical characteristics of the PSMs were determined by FTIR, SEM, XRD, DSC, ESD (equilibrium swelling ratio) and WS (water solubility). The results showed that PSMs could reach its saturated water uptake volume (about 1 mL/100 mg) in 60 s. The PSMs also revealed rough surface with observable pores and lower crystallinity degree after the dual-modification according to SEM and XRD. The use of epichlorohydrin (ECH) as a crosslinking agent could introduce crosslinks between starch molecular chains, which was determined by ESD, WS and the thermal properties. These results indicated that the dual-modification could be successfully used for preparation of rapid water uptake PSMs with enhanced structure stability.
多孔淀粉（PS）是一种多功能的生物材料，已广泛应用于医药和食品工业。本研究通过醇-碱处理的双重改性和反相交联-乳液法来制备一种新型的快速吸水多孔淀粉微球（PSM）。采用 FTIR、SEM、XRD、DSC、ESD（平衡溶胀比）和 WS（水溶性）对 PSM 的化学和物理特性进行了测定。结果表明，PSM 在 60s 内即可达到其饱和水吸收量（约 1mL/100mg）。SEM 和 XRD 结果表明，经过双重改性后，PSM 的表面变得粗糙，出现可见的孔隙，结晶度降低。用环氧氯丙烷（ECH）作为交联剂可以在淀粉分子链之间引入交联，这可以通过 ESD、WS 和热性能来确定。这些结果表明，双重改性可成功用于制备具有增强结构稳定性的快速吸水 PSM。
