Williamson P, Deane S A, Ekberg H, Hawthorne W J, Garvey J F, Stewart G J, Eastman C J, Little J M
Department of Medicine, Westmead Hospital, Australia.
Pancreas. 1988;3(6):646-52. doi: 10.1097/00006676-198812000-00004.
This study examines the endocrine function of duct-obliterated canine segmental autografts for periods up to 5 years posttransplant. Overall the response profile of autografted animals was subnormal. After intravenous glucose tolerance tests K-values in transplanted animals (2.8 +/- 0.9%/min) were significantly lower than normal (4.6 +/- 1.2% min, p less than 0.001). After oral glucose stimulation, blood glucose in the autografted dogs reached a mean peak of 10.6 +/- 2.8 mmol/L whereas in normal dogs the peak value was 6.0 +/- 1.0 mmol/L (p less than 0.002). The mean insulin response in autografted dogs showed lower insulin concentrations in the early stages of the test, whereas insulin secretion after glucagon stimulation was significantly reduced in autografted dogs. Intravenous glucose tolerance tests were analyzed by calculating K value or measuring a single blood glucose concentration 40 min after glucose injection. This value had a high correlation with the K value (r = 0.967). No progressive deterioration of graft function up to 5 years was found. Glycosylated hemoglobin levels were measured in autografted (646 +/- 59 pmol/mg) and normal dogs (620 +/- 85 pmol/mg) and no significant difference was found. In conclusion, duct-occluded segmental pancreatic autografts were shown to have a reduced functional capacity but there was no deterioration of function up to 5 years after duct-occlusion and grafting. The degree of metabolic control may be sufficient to prevent diabetic complications.
本研究对导管闭塞的犬节段性自体移植胰腺长达移植后5年的内分泌功能进行了检测。总体而言，自体移植动物的反应情况低于正常水平。静脉葡萄糖耐量试验后，移植动物的K值（2.8±0.9%/分钟）显著低于正常水平（4.6±1.2%/分钟，p<0.001）。口服葡萄糖刺激后，自体移植犬的血糖平均峰值达到10.6±2.8 mmol/L，而正常犬的峰值为6.0±1.0 mmol/L（p<0.002）。自体移植犬的平均胰岛素反应在试验早期显示胰岛素浓度较低，而胰高血糖素刺激后的胰岛素分泌在自体移植犬中显著减少。静脉葡萄糖耐量试验通过计算K值或在注射葡萄糖40分钟后测量单个血糖浓度进行分析。该值与K值具有高度相关性（r = 0.967）。未发现移植功能在长达5年内有进行性恶化。对自体移植犬（646±59 pmol/mg）和正常犬（620±85 pmol/mg）测量了糖化血红蛋白水平，未发现显著差异。总之，导管闭塞的节段性胰腺自体移植显示功能能力降低，但在导管闭塞和移植后长达5年内功能并未恶化。代谢控制程度可能足以预防糖尿病并发症。
