Khanna Urmi, Dominguez Arturo, Keller Jesse, Kroshinsky Daniela, Ortega-Loayza Alex G, Strowd Lindsay, Micheletti Robert G
Department of Dermatology, Cleveland Clinic, Ohio, USA.
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, USA.
Cutis. 2018 Dec;102(6):395-400.
Calciphylaxis is a rare painful skin condition classically seen in patients with end-stage renal disease (ESRD), particularly those on chronic dialysis; however, it also has been increasingly reported in patients with normal renal function. Calciphylaxis is associated with high mortality rates, and excruciating pain and nonhealing ulcers often lead to recurrent hospitalizations and infectious complications. It is critical for dermatologists to recognize the clinical features of calciphylaxis to ensure accurate and timely diagnosis and proper management. In this article, we provide an update on calciphylaxis etiopathogenesis, diagnosis, and management, and we highlight the challenges faced in managing this potentially fatal condition.
钙过敏是一种罕见的疼痛性皮肤病，典型地见于终末期肾病（ESRD）患者，尤其是那些接受长期透析的患者；然而，肾功能正常的患者中也越来越多地有相关报道。钙过敏与高死亡率相关，剧痛和不愈合的溃疡常常导致反复住院及感染性并发症。皮肤科医生认识钙过敏的临床特征以确保准确、及时的诊断和恰当的治疗至关重要。在本文中，我们提供了关于钙过敏的病因发病机制、诊断和治疗的最新情况，并强调了在处理这种潜在致命疾病时所面临的挑战。
