Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec, QC, Canada; Faculty of Pharmacy, Université Laval, Québec, QC, Canada.
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Québec, QC, Canada.
Atherosclerosis. 2019 Feb;281:89-97. doi: 10.1016/j.atherosclerosis.2018.12.016. Epub 2018 Dec 23.
Recent transversal studies have associated insulin-like growth factor binding protein (IGFBP)-2 levels with glucose tolerance and parameters of the lipoprotein-lipid profile. Here, we aimed at determining the longitudinal effects of a one-year lifestyle modification program on IGFBP-2 levels and to identify specific metabolic improvements impacted by the changes in IGFBP-2.
99 middle-aged Caucasian men were involved in a lifestyle modification program consisting in personalized healthy eating and physical activity counseling, combined to elicit a daily 500 kcal deficit. Anthropometric and metabolic parameters as well as circulating IGFBP-2 levels were measured before and after one year of the lifestyle modification program.
The intervention triggered positive changes in many metabolic parameters and a 43% (p < 0.0001) increase of IGFBP-2 levels. Subjects with the most substantial increases in IGFBP-2 also experienced the most important metabolic improvements. Changes in IGFBP-2 levels (both absolute and relative) were correlated with markers of body fat distribution and lipoprotein-lipid profile, and independently associated with changes in LDL apolipoprotein (apo) B but not VLDL apo B concentrations. Further analyses showed that for similar changes in BMI, waist circumference and visceral adipose tissue volume, large changes in IGFBP-2 levels were required to observe improvements in LDL apo B levels.
The 1-year lifestyle modification program was associated with increased IGFBP-2 concentrations. Increases in IGFBP-2 levels were closely associated with reduced LDL apo B concentrations and independently of the modifications in fat mass and insulin sensitivity. Further mechanistic studies are required to assess the effects of IGFBP-2 levels on LDL metabolism.
最近的横断面研究将胰岛素样生长因子结合蛋白 (IGFBP)-2 水平与葡萄糖耐量和脂蛋白脂质谱参数联系起来。在这里，我们旨在确定为期一年的生活方式改变计划对 IGFBP-2 水平的纵向影响，并确定 IGFBP-2 变化所影响的特定代谢改善。
99 名中年白种人男性参与了一项生活方式改变计划，该计划包括个性化的健康饮食和身体活动咨询，结合每天产生 500 卡路里的热量不足。在生活方式改变计划之前和之后一年，测量了人体测量和代谢参数以及循环 IGFBP-2 水平。
该干预措施引发了许多代谢参数的积极变化，IGFBP-2 水平增加了 43%（p<0.0001）。IGFBP-2 水平增加最多的受试者也经历了最重要的代谢改善。IGFBP-2 水平的变化（绝对值和相对值）与体脂分布和脂蛋白脂质谱的标志物相关，并且与 LDL 载脂蛋白 (apo) B 浓度的变化独立相关，但与 VLDL apo B 浓度无关。进一步的分析表明，对于 BMI、腰围和内脏脂肪组织体积的相似变化，需要 IGFBP-2 水平的较大变化才能观察到 LDL apo B 水平的改善。
为期一年的生活方式改变计划与 IGFBP-2 浓度的增加有关。IGFBP-2 水平的增加与 LDL apo B 浓度的降低密切相关，并且独立于脂肪量和胰岛素敏感性的改变。需要进一步的机制研究来评估 IGFBP-2 水平对 LDL 代谢的影响。
