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脂肪细胞因子在糖和脂代谢中的作用。

Adipokines in glucose and lipid metabolism.

机构信息

Department of Endocrinology, The First Hospital of Jilin University, Jilin, China.

出版信息

Adipocyte. 2023 Dec;12(1):2202976. doi: 10.1080/21623945.2023.2202976.

Abstract

Adipokines are proteins secreted by adipose tissue to regulate glucolipid metabolism and play vital roles in our body. Different adipokines have more than one endocrine function and be divided into several different categories according to their functions, including adipokines involved in glucolipid metabolism, the inflammatory response, insulin action, activation of brown adipose tissue (BAT) and appetite regulation. Multiple adipokines interact with each other to regulate metabolic processes. Based on the recent progress of adipokine research, this article discusses the role and mechanism of various adipokines in glucolipid metabolism, which may provide new ideas for understanding the pathogenesis and improving the treatment of various metabolic diseases.

摘要

脂联素是脂肪组织分泌的蛋白,可调节糖脂代谢,在机体中发挥重要作用。不同的脂联素具有一种以上的内分泌功能,根据其功能可分为几类,包括参与糖脂代谢、炎症反应、胰岛素作用、棕色脂肪组织(BAT)激活和食欲调节的脂联素。多种脂联素相互作用共同调节代谢过程。基于近年来脂联素研究的进展,本文探讨了各种脂联素在糖脂代谢中的作用和机制,这可能为理解各种代谢性疾病的发病机制和改善治疗提供新的思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d28/10120571/cdd44cef7a6c/KADI_A_2202976_F0001_OC.jpg

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