2017 年 McDonald 多发性硬化症诊断标准：特异性降低是否能更早诊断？
2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?
机构信息
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale L.A. Scuro, 10 37134 Verona, Italy.
Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona and Neurology Unit B, Azienda Ospedaliera Universitaria Integrata Verona, Piazzale L.A. Scuro, 10 37134 Verona, Italy.
出版信息
Mult Scler Relat Disord. 2019 Apr;29:23-25. doi: 10.1016/j.msard.2019.01.008. Epub 2019 Jan 3.
BACKGROUND
McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017.
OBJECTIVE
Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE).
METHODS
We retrospectively identified patients with an IDE and collected clinical, MRI and CSF data in order to demonstrate fulfilment of 2010 and 2017 McDonald criteria.
RESULTS
2017 McDonald criteria showed 100% (86.8-100%) sensitivity and 13.8% (3.9-31.7%) specificity.
CONCLUSION
2017 McDonald criteria appear to have higher sensitivity but reduced specificity compared to 2010 McDonald criteria.
背景
多发性硬化症（MS）的麦当劳诊断标准于 2017 年进行了修订。
目的
我们的研究旨在评估和比较 2017 年和 2010 年麦当劳标准在出现首发脱髓鞘事件（IDE）的患者中的敏感性和特异性。
方法
我们回顾性地确定了具有 IDE 的患者，并收集了临床、MRI 和 CSF 数据，以证明满足 2010 年和 2017 年麦当劳标准。
结果
2017 年麦当劳标准的敏感性为 100%（86.8-100%），特异性为 13.8%（3.9-31.7%）。
结论
与 2010 年麦当劳标准相比，2017 年麦当劳标准的敏感性似乎更高，但特异性降低。
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