Anderson Chad J, Kugel Gerard, Gerlach Robert
Private practice, Fresno, CA, USA, chadjandersonαsbcglobal.net.
Department of Comprehensive Care and Associate Dean for Research, School of Dental Medicine, Tufts University, Boston, MA, USA.
Am J Dent. 2018 Dec;31(6):297-302.
To compare the desensitizing effects of two different marketed professional dentin hypersensitivity treatments, a 5% sodium fluoride varnish and an oxalic acid/potassium salt solution, in a single-center, randomized, controlled, subject-blind pilot study.
A total of 22 subjects with dentin hypersensitivity on at least two teeth were recruited from a general dentistry practice and randomized 1:1 to treatment with a 5% sodium fluoride varnish (Acclean Fluoride Varnish) group or a 3% oxalic acid/potassium salt solution (Super Seal Desensitizer). The study population was predominantly female (91%) and Caucasian (77%). The mean age was 46.4 years, with ages ranging from 18-73 years. Dentin hypersensitivity was assessed after an air blast challenge by the examiner (Schiff Index Sensitivity Scale) and by the subject [Visual Analog Scale (VAS)] for each tooth tested. Hypersensitivity was assessed immediately post-treatment and at 2 months post-treatment.
For the sodium fluoride varnish group, the mean Schiff score decreased 61% from baseline immediately post-treatment (P= 0.0006) and 41% at Month 2 (P= 0.0069). For the oxalic acid/potassium salt solution group, the mean Schiff score decreased 33% from baseline immediately post-treatment (P= 0.0305) and 29% at Month 2. Similarly, the mean VAS scores in the sodium fluoride varnish group decreased 41% from baseline immediately post-treatment (P= 0.0030) and 34% at Month 2 (P= 0.0275). The mean VAS scores in the oxalic acid/potassium salt solution group decreased 35% from baseline immediately post-treatment (P= 0.0168) and 33% at Month 2 (P= 0.0283). An analysis of covariance found no statistically significant between-group differences in mean Schiff scores or VAS scores immediately post-treatment or at Month 2. Both treatments were well tolerated. There were no reported adverse events in either treatment group.
Both 5% sodium fluoride varnish and an oxalic acid/potassium salt solution are safe and effective options to treat dentin sensitivity in otherwise healthy adults. The examiner-rated Schiff scores and the patient-rated VAS scores consistently demonstrated a reduction in sensitivity with either treatment, both immediately after professional application and at 2 months post-treatment.
在一项单中心、随机、对照、受试者盲法的试点研究中，比较两种市售的专业牙本质过敏治疗方法，即5%氟化钠清漆和草酸/钾盐溶液的脱敏效果。
从一家普通牙科诊所招募了总共22名至少两颗牙齿患有牙本质过敏的受试者，并将其按1:1随机分为5%氟化钠清漆（Acclean Fluoride Varnish）治疗组或3%草酸/钾盐溶液（Super Seal Desensitizer）治疗组。研究人群以女性为主（91%），白种人占77%。平均年龄为46.4岁，年龄范围在18至73岁之间。在检查者进行气喷刺激后，通过Schiff指数敏感量表对每颗测试牙齿的牙本质过敏情况进行评估，并由受试者通过视觉模拟量表（VAS）进行评估。在治疗后即刻和治疗后2个月评估过敏情况。
对于氟化钠清漆组，治疗后即刻Schiff评分均值较基线下降61%（P = 0.0006），在第2个月时下降41%（P = 0.0069）。对于草酸/钾盐溶液组，治疗后即刻Schiff评分均值较基线下降33%（P = 0.0305），在第2个月时下降29%。同样，氟化钠清漆组的VAS评分均值在治疗后即刻较基线下降41%（P = 0.0030），在第2个月时下降34%（P = 0.0275）。草酸/钾盐溶液组的VAS评分均值在治疗后即刻较基线下降35%（P = 0.0168），在第2个月时下降33%（P = 0.0283）。协方差分析发现，治疗后即刻或第2个月时，两组间Schiff评分均值或VAS评分均值无统计学显著差异。两种治疗方法耐受性良好。两个治疗组均未报告不良事件。
5%氟化钠清漆和草酸/钾盐溶液都是治疗健康成年人牙本质敏感的安全有效选择。检查者评定的Schiff评分和患者评定的VAS评分均一致表明，无论是专业应用后即刻还是治疗后2个月，两种治疗方法均可降低敏感度。
