Department of Periodontology, Dow International Dental College, Dow University of Health Sciences, Karachi, Pakistan.
Department of Operative Dentistry, Dr Ishrat-ul-Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi, Pakistan.
BMC Oral Health. 2024 May 14;24(1):562. doi: 10.1186/s12903-024-04352-0.
Dentin hypersensitivity (DH) is one of the most challenging and persistent dental complaints characterized by transient, intense pain triggered by various stimuli. It affects a significant portion of the global population, predominantly those aged 20-40. This study aims to evaluate the desensitizing efficacy of seventh-generation dentin bonding agents (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) against a control group using Bifluorid 12 by Voco in mitigating DH within a month of the follow-up period.
This was a single-center, parallel-group, double-blind, controlled randomized clinical trial conducted at Dow University of Health Sciences, Karachi, Pakistan. A total of 105 patients with DH were allocated into three groups for this study. The patients were divided into three groups (Single Bond Universal by 3 M ESPE and Xeno-V + by Dentsply) and the control group containing fluoride varnish (Bifluorid 12 by Voco). Discomfort Interval Scale scores and Schiff Cold Air Sensitivity Scale scores were recorded at baseline, immediately after the intervention, after 01 weeks, and after 01 month.
All the materials demonstrated a statistically significant reduction in discomfort and sensitivity (DIS scores p-value 0.01) immediately after 01 week and over a period of 01 month after treatment compared with the baseline scores before application, with no single material proving superior over the one-month observation period. The study also provided insights into dental hygiene practices, with a significant majority using a toothbrush and sensitivity patterns, with cold stimuli being the most common cause of sensitivity.
The study demonstrates that Single Bond Universal, Xeno V+, and Bifluorid 12 are equally effective in reducing dentin hypersensitivity, with no distinct superiority observed over a one-month period. The findings highlight the potential of fluoride varnishes as a less technique-sensitive and cost-effective option for treating DH, offering valuable insights for future research and clinical practice.
NCT04225247 ( https://clinicaltrials.gov/study/NCT04225247 ), Date of Registration: 13/01/2020. (Retrospectively registered).
牙本质过敏症（DH）是一种最具挑战性和持续性的牙科投诉，其特征为各种刺激引起的短暂、剧烈疼痛。它影响了全球很大一部分人口，主要是 20-40 岁的人群。本研究旨在评估第七代牙本质黏结剂（3M ESPE 的 Single Bond Universal 和 Dentsply 的 Xeno-V +）与对照组（沃柯的 Bifluorid 12）在一个月的随访期内对 DH 的脱敏效果。
这是一项在巴基斯坦卡拉奇道大学健康科学中心进行的单中心、平行组、双盲、对照随机临床试验。共有 105 名 DH 患者被分配到三组进行本研究。将患者分为三组（3M ESPE 的 Single Bond Universal 和 Dentsply 的 Xeno-V +）和对照组（沃柯的 Bifluorid 12）。在基线、干预后即刻、01 周后和 01 个月后记录不适间隔量表评分和 Schiff 冷空气敏感性量表评分。
所有材料在 01 周后和治疗后 01 个月与应用前基线评分相比，均显示出统计学上显著降低的不适和敏感性（DIS 评分 p 值 0.01），没有一种材料在一个月的观察期内表现出明显优于其他材料的优势。该研究还提供了有关口腔卫生实践的见解，大多数人使用牙刷，并且有冷刺激敏感性模式，冷刺激是最常见的敏感原因。
该研究表明，Single Bond Universal、Xeno V+和 Bifluorid 12 在降低牙本质过敏症方面同样有效，在一个月的时间内没有明显的优势。研究结果突出了氟化物漆作为一种技术敏感性较低且具有成本效益的治疗 DH 的选择的潜力，为未来的研究和临床实践提供了有价值的见解。
NCT04225247（https://clinicaltrials.gov/study/NCT04225247），注册日期：2020 年 1 月 13 日（回顾性注册）。
