O'Reilly R A, Taber B Z
Obstet Gynecol. 1978 May;51(5):590-7. doi: 10.1097/00006250-197805000-00018.
Six new cases of idiopathic thrombocytopenic purpura (ITP) associated with pregnancy are reported; one of these patients delivered triplets. In addition, 78 patients with 122 pregnancies and 124 fetuses have been reported previously. The maternal mortality rate was 4% and the fetal mortality rate was 18%. Prior recommendations for elective cesarean section in all mothers with a platelet count less than 100,000/cu mm at delivery is not supported by the data available. Treatment of pregnant women with ITP with adrenal corticosteroids has virtually eliminated maternal mortality, has replaced splenectomy as the therapy of choice during pregnancy, but has had little effect on fetal mortality.
报告了6例与妊娠相关的特发性血小板减少性紫癜（ITP）新病例；其中1例患者分娩了三胞胎。此外，此前已报告78例患者，共122次妊娠和124个胎儿。孕产妇死亡率为4%，胎儿死亡率为18%。现有数据不支持之前对所有分娩时血小板计数低于100,000/立方毫米的母亲进行选择性剖宫产的建议。用肾上腺皮质类固醇治疗妊娠ITP患者实际上已消除了孕产妇死亡，在孕期已取代脾切除术成为首选治疗方法，但对胎儿死亡率影响不大。
