Ovule development is critical for seed development and plant reproduction. Multiple transcription factors (TFs) have been reported to mediate ovule development. However, it is not clear which intracellular components regulate these TFs during ovule development. After their synthesis, TFs are transported into the nucleus a process regulated by karyopherins commonly known as importin alpha and β. Around half of Arabidopsis () importin β-coding genes have been functionally characterized but only two with specific cargos have been identified. We report here that Arabidopsis IMPORTIN β4 (IMB4) regulates ovule development through nucleocytoplasmic transport of transcriptional coactivator growth regulating factors-interacting factors (GIFs). Mutations in impaired ovule development by affecting integument growth. mutants were also defective in embryo sac development, leading to partial female sterility. IMB4 directly interacts with GIFs and is critical for the nucleocytoplasmic transport of GIF1. Finally, functional loss of s resulted in ovule defects similar to those in mutants, whereas enhanced expression of partially restored the fertility of The results presented here uncover a novel genetic pathway regulating ovule development and reveal the upstream regulator of GIFs.