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J Allergy Clin Immunol. 2019 May;143(5):1934-1937.e4. doi: 10.1016/j.jaci.2018.10.071. Epub 2019 Jan 17.
2
Efficacy of oral corticosteroids in the treatment of acute wheezing episodes in asthmatic preschoolers: Systematic review with meta-analysis.口服皮质类固醇治疗学龄前哮喘儿童急性喘息发作的疗效：系统评价与荟萃分析
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An update on the efficacy of oral corticosteroids in the treatment of wheezing episodes in preschool children.口服皮质类固醇治疗学龄前儿童喘息发作疗效的最新进展。
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本文引用的文献

1
Can we predict fall asthma exacerbations? Validation of the seasonal asthma exacerbation index.我们能否预测秋季哮喘发作？季节性哮喘发作指数的验证。
J Allergy Clin Immunol. 2017 Oct;140(4):1130-1137.e5. doi: 10.1016/j.jaci.2017.01.026. Epub 2017 Feb 24.
2
Individualized therapy for persistent asthma in young children.幼儿持续性哮喘的个体化治疗。
J Allergy Clin Immunol. 2016 Dec;138(6):1608-1618.e12. doi: 10.1016/j.jaci.2016.09.028. Epub 2016 Oct 21.
3
The dilemma of systemic steroids in preschool children with recurrent wheezing exacerbations.全身用类固醇激素在反复喘息加重的学龄前儿童中的困境
Pediatr Pulmonol. 2016 Aug;51(8):775-7. doi: 10.1002/ppul.23465. Epub 2016 May 9.
4
Should a Preschool Child with Acute Episodic Wheeze be Treated with Oral Corticosteroids? A Pro/Con Debate.患有急性发作性喘息的学龄前儿童是否应接受口服皮质类固醇治疗？一场正反方辩论。
J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):27-35. doi: 10.1016/j.jaip.2015.10.017.
5
Systematic review of the toxicity of short-course oral corticosteroids in children.儿童短期口服皮质类固醇毒性的系统评价
Arch Dis Child. 2016 Apr;101(4):365-70. doi: 10.1136/archdischild-2015-309522. Epub 2016 Jan 14.
6
Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial.阿奇霉素早期给药与预防有严重下呼吸道疾病病史的学龄前儿童发生此类严重疾病：一项随机临床试验
JAMA. 2015 Nov 17;314(19):2034-2044. doi: 10.1001/jama.2015.13896.
7
Seasonal risk factors for asthma exacerbations among inner-city children.城市内儿童哮喘发作的季节性风险因素。
J Allergy Clin Immunol. 2015 Jun;135(6):1465-73.e5. doi: 10.1016/j.jaci.2014.12.1942. Epub 2015 Mar 18.
8
The Pediatric Respiratory Assessment Measure: a valid clinical score for assessing acute asthma severity from toddlers to teenagers.儿童呼吸评估量表：一种用于评估从幼儿到青少年急性哮喘严重程度的有效临床评分。
J Pediatr. 2008 Apr;152(4):476-80, 480.e1. doi: 10.1016/j.jpeds.2007.08.034. Epub 2007 Oct 31.
9
Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial.甲基强的松龙治疗婴幼儿急性哮喘：一项对照临床试验。
Pediatrics. 1990 Sep;86(3):350-6.

评估全身皮质类固醇治疗学龄前儿童严重喘息发作疗效的挑战。

Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children.

机构信息

Department of Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Department of Pediatrics, Washington University in St Louis School of Medicine, St Louis, Mo.

出版信息

J Allergy Clin Immunol. 2019 May;143(5):1934-1937.e4. doi: 10.1016/j.jaci.2018.10.071. Epub 2019 Jan 17.

DOI:10.1016/j.jaci.2018.10.071
PMID:30660645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6504562/
Abstract

This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.

摘要

这封信针对在学龄前儿童喘息加重期间使用口服皮质类固醇这一有争议的问题，展示了一项提前终止的多中心临床试验的结果，讨论了所吸取的经验教训，并提出了未来的方向。