Minkova M I, Pantev T P
Institute of Röentgenology and Radiobiology, Medical Academy, Sofia, Bulgaria.
Acta Physiol Pharmacol Bulg. 1988;14(2):63-70.
Experiments were carried out to investigate the possibility of providing chemical protection to blood forming organs and increasing animal survival rates in lethally irradiated H mice and Wistar rats. A 300 mg/kg dose of the radioprotective agent was injected intraperitoneally 15-30 min prior to irradiation with 8.0 Gy gamma rays. Recorded were 30-day survival rates and the state of hemopoiesis on days 3 and 10 postradiation as judged by spleen weight and total counts of spleno- and myelokaryocytes. At 8.0 Gy exposure was observed to cause severe spleen and bone-marrow hypoplasia on day 3 postradiation. Adeturone pretreatment provided slight protection to rat spleen and mouse bone marrow; by day 10, however, both animal species exhibited a vigorous proliferative response of nucleated cells in the bone marrow, which resulted in 75% survival rate among animals exposed to a lethal radiation dose.
开展了实验，以研究对造血器官提供化学防护并提高致死剂量照射的H小鼠和Wistar大鼠存活率的可能性。在8.0 Gyγ射线照射前15 - 30分钟，腹腔注射300 mg/kg剂量的辐射防护剂。记录30天存活率以及辐射后第3天和第10天的造血状态，通过脾脏重量以及脾和骨髓有核细胞总数来判断。在8.0 Gy照射剂量下，辐射后第3天观察到脾脏和骨髓严重发育不全。阿德图龙预处理对大鼠脾脏和小鼠骨髓有轻微保护作用；然而，到第10天，两种动物的骨髓有核细胞均表现出强烈的增殖反应，这使得接受致死辐射剂量的动物存活率达到75%。
