Azadian Esmaeel, Arjmand Bahar, Khodaii Zohreh, Ardeshirylajimi Abdolreza
a Urogenital Stem Cell Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
b Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Electromagn Biol Med. 2019;38(1):1-20. doi: 10.1080/15368378.2019.1567527. Epub 2019 Jan 19.
Stem cells are one of the most important sources to develope a new strategy for repairing bone lesions through tissue engineering. Osteogenic differentiation of stem cells can be affected by various factors such as biological, chemical, physiological, and physical ones. The application of ELF-EMFs has been the subject of many research in bone tissue engineering and evidence suggests that this exogenous physical stimulus can promote osteogenic differentiation in several types of cells. The purpose of this paper is to review the current knowledge on the effects of EMFs on stem cells in bone tissue engineering studies. We recapitulated and analyzed 39 articles that were focused on the application of EMFs for bone tissue engineering purposes. We tabulated scattered information from these articles for easy use and tried to provide an overview of conducted research and identify the knowledge gaps in the field.
干细胞是通过组织工程开发修复骨缺损新策略的最重要来源之一。干细胞的成骨分化会受到多种因素的影响,如生物学、化学、生理学和物理因素。极低频电磁场(ELF-EMFs)的应用一直是骨组织工程中许多研究的主题,有证据表明这种外源性物理刺激可以促进几种类型细胞的成骨分化。本文的目的是综述骨组织工程研究中关于电磁场对干细胞影响的现有知识。我们总结并分析了39篇专注于将电磁场应用于骨组织工程目的的文章。我们将这些文章中分散的信息制成表格以便于使用,并试图概述已进行的研究并确定该领域的知识空白。
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