National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
Department of Biomaterials and Tissue Engineering, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Tissue Eng Regen Med. 2022 Dec;19(6):1147-1160. doi: 10.1007/s13770-022-00473-1. Epub 2022 Aug 30.
Low-frequency electromagnetic fields (EMFs) influence biological processes. This present study was aimed at the scientific literature on the use of EMFs in the mesenchymal stem cell differentiation process.
The electronic search was carried out in PubMed and Web of Science, a database with a combination of the sinusoidal and pulsed low- and extremely low-frequency electromagnetic fields stimulation and mesenchymal stem cells differentiation, considering the period of publication until December 2021. The literature search identified 118 references in PubMed and Web of Science of which 46 articles were selected, respectively, according to the eligibility requirements.
The analysis of research indicated that EMFs are an easy-to-apply and practical way in cell therapy and tissue engineering when regulation of stem cells is required. Studies have shown that EMFs have positive effects on stem cell differentiation, accelerating its process regardless of the parameters and type of stem cells. However, the exact amplitude, frequency, duration of the electrical field, and application method remain elusive and need more study in future work.
低频电磁场（EMF）会影响生物过程。本研究旨在探讨电磁场在间充质干细胞分化过程中的应用的科学文献。
在 PubMed 和 Web of Science 数据库中进行了电子检索，该数据库结合了正弦波和脉冲低频和极低频电磁场刺激与间充质干细胞分化，考虑到出版时间截至 2021 年 12 月。文献检索在 PubMed 和 Web of Science 中分别识别出 118 篇参考文献，根据资格要求，分别选择了 46 篇文章。
研究分析表明，当需要调节干细胞时，电磁场是细胞治疗和组织工程中一种易于应用和实用的方法。研究表明，电磁场对干细胞分化有积极影响，无论干细胞的参数和类型如何，都能加速其分化过程。然而，确切的电场幅度、频率、持续时间和应用方法仍不清楚，需要在未来的工作中进行更多的研究。
