Yoshimizu Satoru, Hirose Fumitaka, Takagi Seiji, Fujihara Masashi, Kurimoto Yasuo
Department of Ophthalmology, Kobe City Eye Hospital, 2-1-8, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Department of Ophthalmology, Kobe City Medical Center General Hospital, 2-1-1, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Jpn J Ophthalmol. 2019 Mar;63(2):151-157. doi: 10.1007/s10384-019-00651-0. Epub 2019 Jan 20.
To compare pretreatment anterior segment parameters between eyes with acute primary angle closure (APAC) and chronic primary angle closure (CPAC), and to identify the characteristics of eyes with APAC.
Retrospective.
We measured pretreatment anterior chamber depth (ACD), iris convexity (IC), and pupil diameter in eyes with APAC and CPAC using anterior segment optical coherence tomography. The risk of APAC associated with anterior segment parameters was investigated using multiple logistic regression. Eyes with APAC were discriminated from eyes with CPAC using the receiver-operating characteristic (ROC) curve and area under the curve (AUC). The best cutoff for these variables was determined.
Thirty-four eyes with APAC and 60 eyes with CPAC were included. The mean intraocular pressure was 52.3 ± 12.6 mmHg in APAC and 15.5 ± 3.5 mmHg in CPAC (P < .001). Eyes with APAC had a shallower ACD (1.407 ± 0.301 mm vs. 1.960 ± 0.205 mm, P < .001) and less IC (0.233 ± 0.087 mm vs. 0.294 ± 0.068 mm, P < .001) than eyes with CPAC. In multivariate analysis, significant variables associated with APAC were ACD (P < .001) and IC (P = .001). The AUC for ACD was 0.931 and for IC, 0.742. The best cutoff for ACD was 1.699 mm (sensitivity 0.824, specificity 0.917) and for IC, 0.282 mm (sensitivity 0.853, specificity 0.533).
Eyes with APAC had a shallower ACD and less IC. Eyes with an ACD < 1.7 mm may be at risk for APAC.
比较急性原发性闭角型青光眼（APAC）和慢性原发性闭角型青光眼（CPAC）患者治疗前眼前节参数，确定APAC患者的眼部特征。
回顾性研究。
我们使用眼前节光学相干断层扫描测量了APAC和CPAC患者治疗前的前房深度（ACD）、虹膜凸度（IC）和瞳孔直径。使用多因素逻辑回归研究与眼前节参数相关的APAC风险。使用受试者操作特征（ROC）曲线和曲线下面积（AUC）区分APAC和CPAC患者。确定这些变量的最佳截断值。
纳入34例APAC患者和60例CPAC患者。APAC患者的平均眼压为52.3±12.6 mmHg，CPAC患者为15.5±3.5 mmHg（P<0.001）。与CPAC患者相比，APAC患者的ACD更浅（1.407±0.301 mm对1.960±0.205 mm，P< .001），IC更小（0.233±0.087 mm对0.294±0.068 mm，P< .001）。在多因素分析中，与APAC相关的显著变量是ACD（P< .001）和IC（P = .001）。ACD的AUC为0.931，IC的AUC为0.742。ACD的最佳截断值为1.699 mm（敏感性0.824，特异性0.917），IC的最佳截断值为0.282 mm（敏感性0.853，特异性0.533）。
APAC患者的ACD更浅，IC更小。ACD<1.7 mm的患者可能有患APAC的风险。
