Technology Center, Food Chemistry Physical Analysis Laboratory, Cariri Faculty of Technology, Juazeiro do Norte, Brazil.
Department of Biological Chemistry, Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, Brazil.
Nat Prod Res. 2020 Nov;34(22):3239-3243. doi: 10.1080/14786419.2018.1552955. Epub 2019 Jan 19.
In this study the physicochemical characterization of the pulp and almond fixed oil was carried out; their antibacterial activity and aminoglycoside antibiotic modifying action against standard and multiresistant Gram-positive and -negative bacteria were investigated using the broth microdilution assay. Physical properties such as moisture, pH, acidity, peroxide index, relative density and refractive index indicate stability and chemical quality of the oils. In the GC/MS chemical composition analysis, a high unsaturated fatty acid content and the presence of oleic and palmitic acids were observed in the oils. In the antibacterial assay, more significant results were obtained for , while other standard and multi-resistant strains presented MIC values ≥ 1024 μg/mL. Furthermore, the fixed oils in association with antibiotics were able to significantly improve antibacterial activity against with a reduction in MICs.
本研究对果肉和巴旦木固定油进行了理化特性分析，并采用肉汤微量稀释法检测了它们对标准和多耐药革兰氏阳性和阴性菌的抗菌活性和氨基糖苷类抗生素修饰作用。物理性质如水分、pH 值、酸度、过氧化物指数、相对密度和折射率表明了油的稳定性和化学质量。在 GC/MS 化学成分分析中，观察到油中含有高不饱和脂肪酸和油酸、棕榈酸。在抗菌试验中，对 ，得到了更显著的结果，而其他标准和多耐药菌株的 MIC 值≥1024μg/ml。此外，固定油与抗生素联合使用能够显著提高对 的抗菌活性，降低 MIC 值。
