School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.
Nat Prod Res. 2020 May;34(9):1337-1340. doi: 10.1080/14786419.2018.1560293. Epub 2019 Jan 19.
is widely used in the clinic of traditional Chinese medicine. In order to enlarge the range of application, it is necessary to processed with honey, salt-water, and rice-wine, respectively. We hope to elucidate the connotation of processing, an UPLC-QqQ-MS method was used for determination and comparison the tissue distribution of alkaloids and triterpenes after oral administration water-extracts of crude and processed products. The results showed that the berberine, phellodendrine, magnoflorine, limonin, and obacunone in crude and processed products were distributed in all tissues, especially in the small intestine and stomach. In this study, we can provide a scientific basis for explaining the processing connotation of processed with salt-water and rice-wine, respectively.
炙法在中医临床中广泛应用。为了扩大应用范围，需要分别用蜂蜜、盐水和米酒进行炮制。为了阐明炮制的内涵，本研究采用 UPLC-QqQ-MS 法测定和比较了生品和炮制品水提物给药后生物碱和三萜类成分的组织分布。结果表明，黄连、黄柏、厚朴、柠檬苦素和莪术酮在生品和炮制品中均分布于所有组织，尤其是在小肠和胃中。本研究可为分别用盐水和米酒炮制提供科学依据。
