Neurology Unit, Department of Translational Medicine, AOU Maggiore della Carità and University of Piemonte Orientale, Novara, Italy.
Neurology Unit, Department of Medical Sciences, IRCCS, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Neurol Sci. 2019 Apr;40(4):759-762. doi: 10.1007/s10072-019-3724-z. Epub 2019 Jan 21.
Lumbar puncture (LP) is a safe procedure commonly performed in the diagnostic work-up of multiple sclerosis (MS), and its main adverse event is post-LP headache (PLPH). Predictors for PLPH in MS are not established.
To describe the occurrence of, and, factors related to PLPH in patients with suspected MS, studied on a daily-basis admission.
One hundred patients (70 females) were admitted for a diagnostic LP (standardized with a traumatic 19-G needle), observed for 6 h, and evaluated for adverse events 2 and 7 days later. Descriptive statistics and a multivariate analysis (for PLPH) were performed.
Fifty-seven (57%) patients had PLPH at 48 h, which persisted 1 week in 31, and only two presented beyond the first 2 days. Other adverse events were tinnitus and neck stiffness. None required investigations or was hospitalized. Age was the only predictor for PLPH at day 2, whereas the onset of headache within 48 h and female gender were predictors for PLPH at day 7.
PLPH is a frequent complication of LP performed on daily-basis admission in MS work-up. The maximum onset is within the first 48 h. Age and gender seem the only predictors for the appearance and persistence of PLPH.
腰椎穿刺（LP）是多发性硬化症（MS）诊断过程中常用的安全程序，其主要的不良事件是腰椎穿刺后头痛（PLPH）。MS 患者发生 PLPH 的预测因素尚未确定。
描述疑似 MS 患者在每日入院时接受 LP 检查后 PLPH 的发生情况，以及与 PLPH 相关的因素。
100 例患者（70 例女性）接受了诊断性 LP（用创伤性 19-G 针标准化），观察 6 小时，并在第 2 天和第 7 天评估不良事件。进行描述性统计和多变量分析（用于 PLPH）。
57 例（57%）患者在 48 小时时有 PLPH，其中 31 例持续到第 1 周，仅 2 例在第 2 天之后出现。其他不良事件包括耳鸣和颈部僵硬。没有需要调查或住院的情况。年龄是第 2 天发生 PLPH 的唯一预测因素，而头痛在 48 小时内发作和女性性别是第 7 天发生 PLPH 的预测因素。
PLPH 是 MS 诊断性 LP 检查中常见的并发症。最大发病时间在 48 小时内。年龄和性别似乎是 PLPH 出现和持续的唯一预测因素。
