Solid State Chemistry, Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen, 6525AJ, The Netherlands.
Chemistry. 2019 Mar 12;25(15):3756-3760. doi: 10.1002/chem.201805276. Epub 2019 Feb 13.
Two-dimensional polymers (2DP) are a new class of materials that consist of a monolayer of ordered molecular building blocks, which have been covalently linked. One of these monomers was self-assembled on a flat muscovite mica scaffold and subsequently the organic layer was polymerized. The resulting flat and stable 2DP layer was used as a template for protein crystallization. Crystals of insulin were epitaxially grown on the template, whereas insulin crystals grown on clean muscovite mica had a random orientation. The template was selective, considering that no epitaxially ordered crystals formed of hen egg white lysozyme, bovine serum albumin, or talin.
二维聚合物（2DP）是一类新型材料，由单层有序分子构建块通过共价键连接而成。这些单体中的一个在平坦的白云母支架上自组装，然后有机层聚合。所得的平坦且稳定的 2DP 层被用作蛋白质结晶的模板。胰岛素晶体在模板上外延生长，而在清洁的白云母上生长的胰岛素晶体则具有随机取向。该模板具有选择性，因为没有形成鸡卵清白溶菌酶、牛血清白蛋白或桩蛋白的外延有序晶体。
