β-肾上腺素能受体基因多态性与冠心病患者心血管事件相关，但与全因死亡率无关：前瞻性研究的荟萃分析

β-Adrenergic Receptor Gene Polymorphisms Are Associated with Cardiovascular Events But not All-Cause Mortality in Coronary Artery Disease Patients: A Meta-Analysis of Prospective Studies.

作者信息

Li Yanrong, Yuan Huiping, Sun Liang, Zhou Qi, Yang Fan, Yang Ze, Liu Deping

机构信息

1 Department of Cardiology, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.

2 The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.

出版信息

Genet Test Mol Biomarkers. 2019 Feb;23(2):124-137. doi: 10.1089/gtmb.2018.0153. Epub 2019 Jan 22.

DOI:10.1089/gtmb.2018.0153

PMID:30668166

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6383583/

Abstract

AIMS

β-Adrenergic receptors (ADRBs) play a pivotal role in cardiovascular disease. Recently, genetic polymorphisms of ADRB1 and ADRB2 have been suggested to be associated with cardiovascular events and all-cause mortality in coronary artery disease (CAD) patients, but the results of relevant studies are inconsistent and controversial. Therefore, we performed a meta-analysis to investigate the association between ADRB1 and ADRB2 polymorphisms with cardiovascular events and all-cause mortality in CAD patients.

MATERIALS AND METHODS

The PubMed, Ovid, EMBASE, Cochrane, and CINAHL databases were searched for eligible studies published before April 2018. A total of 5495 patients from eight studies were included in our meta-analysis.

RESULTS

We found that CAD patients harboring the ADRB2 rs1042714 Glu27 allele exhibited a positive association with cardiovascular events (risk ratio [RR] = 1.31, 95% confidence interval [CI]: 1.08-1.58, p = 0.006), but not with all-cause mortality (RR = 0.97, 95% CI: 0.70-1.35, p = 0.859), compared with patients who were Gln27 homozygotes. No other significant associations were observed between ADRB1 (rs1801252, rs1801253), ADRB2 (rs1042713, rs1800888) polymorphisms and cardiovascular events or all-cause mortality in CAD patients.

CONCLUSION

This study suggests that the identified ADRB2 polymorphism could influence the outcomes of CAD patients, showing important clinical value.

摘要

目的

β-肾上腺素能受体（ADRBs）在心血管疾病中起关键作用。最近，有人提出ADRB1和ADRB2的基因多态性与冠心病（CAD）患者的心血管事件和全因死亡率相关，但相关研究结果并不一致且存在争议。因此，我们进行了一项荟萃分析，以研究ADRB1和ADRB2基因多态性与CAD患者心血管事件和全因死亡率之间的关联。

材料与方法

检索了PubMed、Ovid、EMBASE、Cochrane和CINAHL数据库，以查找2018年4月之前发表的符合条件的研究。我们的荟萃分析纳入了来自八项研究的共5495例患者。

结果

我们发现，与携带Gln27纯合子的患者相比，携带ADRB2 rs1042714 Glu27等位基因的CAD患者与心血管事件呈正相关（风险比[RR]=1.31，95%置信区间[CI]：1.08-1.58，p=0.006），但与全因死亡率无关（RR=0.97，95%CI：0.70-1.35，p=0.859）。在CAD患者中，未观察到ADRB1（rs1801252、rs1801253）、ADRB2（rs1042713、rs1800888）基因多态性与心血管事件或全因死亡率之间的其他显著关联。