Department of Physiology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Martin, Slovakia.
Physiol Res. 2021 Dec 30;70(Suppl4):S495-S510. doi: 10.33549/physiolres.934799.
Adrenergic receptors (ARs) are the primary targets of catecholamines released from the sympathetic nerve endings during their activation. ARs play a central role in autonomic nervous system and serve as important targets of widely used drugs. Several ARs gene polymorphisms were found to be associated with cardiovascular disease in previous clinical studies. Although more precise mechanism of the polymorphisms influence on autonomic control of cardiovascular system was studied in many previous physiological studies, their results are not unequivocal. This paper reviews the results of clinical and physiological studies focused on the impact of selected common single nucleotide polymorphisms of ARs genes involved in sympathetic control on cardiovascular system and its control. In summary, many studies assessed only a very limited range of cardiovascular control related parameters providing only very limited view on the complex cardiovascular control. The overview of partially contradicting results underlines a need to examine wider range of cardiovascular measures including their reactivity under various stress conditions requiring further study. It is expected that an effect of one given polymorphism is not very prominent, but it is suggested that even subtle differences in cardiovascular control could - on a longer time scale - lead to the development of severe pathological consequences.
肾上腺素能受体（ARs）是去甲肾上腺素从交感神经末梢释放时激活的主要靶点。ARs 在自主神经系统中发挥核心作用，是广泛使用的药物的重要靶点。在以前的临床研究中发现，几种 ARs 基因多态性与心血管疾病有关。尽管在许多以前的生理学研究中已经研究了多态性对心血管系统自主控制的影响的确切机制，但它们的结果并不明确。本文综述了关注参与交感神经控制的 ARs 基因的选定常见单核苷酸多态性对心血管系统及其控制影响的临床和生理学研究的结果。总之，许多研究仅评估了非常有限的心血管控制相关参数范围，仅对复杂的心血管控制提供了非常有限的了解。部分相互矛盾的结果概述强调需要进一步研究，以检查更广泛的心血管措施，包括它们在各种应激条件下的反应性。预计一个给定的多态性的影响不会很显著，但据推测，即使在心血管控制方面存在细微差异，也可能会在较长时间内导致严重的病理后果。
