Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Japan.
Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, Japan.
Clin Neurophysiol. 2019 Mar;130(3):341-351. doi: 10.1016/j.clinph.2018.11.026. Epub 2018 Dec 28.
Patients with mesial temporal lobe epilepsy (mTLE) often exhibit central auditory processing (CAP) dysfunction. Monaural 40-Hz auditory steady-state magnetic responses (ASSRs) were recorded to explore the pathophysiology of mTLE.
Eighteen left mTLE patients, 11 right mTLE patients and 16 healthy controls (HCs) were examined. Monaural clicks were presented at a rate of 40 Hz. Phase-locking factor (PLF) and power values were analyzed within bilateral Heschl's gyri.
Monaural 40-Hz ASSR demonstrated temporal frequency dynamics in both PLF and power data. Symmetrical hemispheric contralaterality was revealed in HCs. However, predominant contralaterality was absent in mTLE patients. Specifically, right mTLE patients exhibited a lack of contralaterality in response to left ear but not right ear stimulation, and vice versa in left mTLE patients.
This is the first study to use monaural 40-Hz ASSR with unilateral mTLE patients to clarify the relationship between CAP and epileptic focus. CAP dysfunction was characterized by a lack of contralaterality corresponding to epileptic focus.
Monaural 40-Hz ASSR can provide useful information for localizing epileptic focus in mTLE patients.
内侧颞叶癫痫（mTLE）患者常表现出中枢听觉处理（CAP）功能障碍。本研究旨在通过记录单耳 40-Hz 听觉稳态磁响应（ASSR），探讨 mTLE 的病理生理学机制。
本研究纳入 18 例左侧 mTLE 患者、11 例右侧 mTLE 患者和 16 例健康对照者（HCs）。以 40Hz 的速率呈现单耳 click。在双侧 Heschl 回内分析相位锁定因子（PLF）和功率值。
单耳 40-Hz ASSR 在 PLF 和功率数据中均表现出时间频率动态变化。HCs 呈现出对称的半球对侧性。然而，mTLE 患者则不存在优势对侧性。具体而言，右侧 mTLE 患者对左耳刺激无反应，而对右耳刺激有反应，反之亦然；左侧 mTLE 患者则表现出相反的模式。
这是第一项使用单耳 40-Hz ASSR 研究单侧 mTLE 患者的 CAP 与癫痫灶之间关系的研究。CAP 功能障碍的特征是与癫痫灶相对应的缺乏对侧性。
单耳 40-Hz ASSR 可以为 mTLE 患者的癫痫灶定位提供有用的信息。
