替加环素对包括耐万古霉素肠球菌和金黄色葡萄球菌在内的肠球菌和葡萄球菌的疗效：一项在小鼠腹膜炎模型中的研究。
Efficacy of Tedizolid against Enterococci and Staphylococci, Including Strains, in a Mouse Peritonitis Model.
机构信息
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
UTHealth Center for Antimicrobial Resistance and Microbial Genomics (CARMiG), Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2019 Mar 27;63(4). doi: 10.1128/AAC.02627-18. Print 2019 Apr.
Abstract
In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an strain (VAN, AMP), an strain, and a methicillin-resistant (MRSA) strain with and without Against a (B), tedizolid was inferior to linezolid and daptomycin, despite an ∼4-fold lower MIC.
摘要
在一项腹膜炎小鼠模型研究中，替加环素与利奈唑胺和达托霉素相比，对一株万古霉素中介金黄色葡萄球菌（VAN，AMP）、一株耐青霉素金黄色葡萄球菌（MRSA）和一株耐甲氧西林金黄色葡萄球菌（MRSA）具有相当的疗效，且无论是否存在 ，替加环素的疗效均逊于利奈唑胺和达托霉素，尽管其 MIC 低约 4 倍。
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