Chief Scientific Advisor and Academic Editor, Science Signaling, American Association for the Advancement of Science, Washington, DC 20005, USA.
David H. Koch Institute for Integrative Cancer Research, MIT Center for Precision Cancer Medicine, Broad Institute, and the Departments of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sci Signal. 2019 Jan 22;12(565):eaaw3483. doi: 10.1126/scisignal.aaw3483.
Genetic approaches to cancer research have dramatically advanced our understanding of the pathophysiology of this disease, leading to similar genetics-based approaches for precision therapy, which have been less successful. Reconfiguring and adapting the types of technologies that underlie genetic research to dissect tumor cell signaling in clinical samples may offer an alternative road forward.
基因方法在癌症研究方面取得了显著进展，使我们对这种疾病的病理生理学有了更深入的了解，并在此基础上提出了类似的基于遗传学的精准治疗方法，但效果并不理想。重新配置和调整基因研究的基础技术类型，以剖析临床样本中的肿瘤细胞信号，可能是一种前进的替代方法。
