Epperlein H H
Anatomisches Institut der Universität, Freiburg.
Naturwissenschaften. 1988 Sep;75(9):443-50. doi: 10.1007/BF00364024.
Neural crest cells give rise to various essential tissues in vertebrates. Among these are the teeth, the ganglia of the peripheral nervous system, endocrine cells and pigment cells. Neural crest cells are actively migrating cells, but their migration needs to be stimulated by an appropriate extracellular matrix (ECM). In the present article the role of the epidermis and subepidermal ECM during the migration of neural crest cells and their differentiation into pigment cells in amphibian embryos will be considered. Furthermore, a new microcarrier technique will be presented with which the influence of natural ECM and various ECM components on the behavior and differentiation of neural crest derivatives can be investigated in amphibian embryos.
神经嵴细胞产生脊椎动物体内各种重要组织。其中包括牙齿、外周神经系统的神经节、内分泌细胞和色素细胞。神经嵴细胞是活跃迁移的细胞，但其迁移需要由合适的细胞外基质（ECM）来刺激。在本文中，将探讨表皮和表皮下ECM在两栖类胚胎神经嵴细胞迁移及其分化为色素细胞过程中的作用。此外，还将介绍一种新的微载体技术，利用该技术可以在两栖类胚胎中研究天然ECM和各种ECM成分对神经嵴衍生物的行为和分化的影响。
