Omata K, Kawamura H
Department of Neuroscience, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Neurosci Lett. 1988 Dec 19;95(1-3):218-22. doi: 10.1016/0304-3940(88)90660-x.
To investigate the circadian system of the golden hamster, multiple unit activity (MUA) was recorded inside and outside the suprachiasmatic nucleus (SCN). MUA inside the SCN showed a daily rhythm with a daytime peak during a 24 h light-dark cycle (LD, 12:12), whereas MUA outside the SCN revealed a nighttime peak. The phase reversal of MUA between inside and outside the SCN in the golden hamster was similar to the rat which is also a nocturnal rodent. MUA rhythms to the lighting cycle started to freerun after methamphetamine administration. This result indicates that methamphetamine may affect directly the neural circadian oscillator to induce behavioral change.
为了研究金黄地鼠的昼夜节律系统，在视交叉上核（SCN）内外记录了多单位活动（MUA）。在24小时明暗循环（LD，12:12）期间，SCN内的MUA呈现出每日节律，白天达到峰值，而SCN外的MUA则在夜间达到峰值。金黄地鼠SCN内外MUA的相位反转与同样是夜行性啮齿动物的大鼠相似。给予甲基苯丙胺后，MUA对光照周期的节律开始自由运行。这一结果表明，甲基苯丙胺可能直接影响神经昼夜振荡器，从而引起行为变化。
