维生素B6缺乏的神经内分泌学

Neuroendocrinology of pyridoxine deficiency.

作者信息

Dakshinamurti K, Paulose C S, Viswanathan M, Siow Y L

机构信息

Department of Biochemistry, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

出版信息

Neurosci Biobehav Rev. 1988 Fall-Winter;12(3-4):189-93. doi: 10.1016/s0149-7634(88)80040-x.

DOI:10.1016/s0149-7634(88)80040-x

PMID:3067155

Abstract

Dihydroxyphenylalanine decarboxylase and 5-hydroxytryptophan decarboxylase respectively have high and low affinities for pyridoxal phosphate. In the pyridoxine-deficient animal, hypothalamic serotonin content is significantly reduced without any change in catecholamine levels. Hypothalamic neurotransmitters affect the hypothalamo-pituitary-end organ axes. Specifically, the decrease in hypothalamic serotonin in the pyridoxine-deficient rat results in tertiary hypothyroidism. In addition, pineal function is affected in deficient animals due to decreased synthesis of melatonin.

摘要

二羟基苯丙氨酸脱羧酶和5-羟色氨酸脱羧酶分别对磷酸吡哆醛具有高亲和力和低亲和力。在缺乏维生素B6的动物中，下丘脑5-羟色胺含量显著降低，而儿茶酚胺水平无任何变化。下丘脑神经递质会影响下丘脑-垂体-终末器官轴。具体而言，缺乏维生素B6的大鼠下丘脑5-羟色胺减少会导致三期甲状腺功能减退。此外，由于褪黑素合成减少，缺乏维生素B6的动物松果体功能也会受到影响。