Maillefer Aude, Sabe Michel, Coste Christophe, Bartolomei Javier, Jaafar Jaafar, Sentissi Othman
Clinique Belle Idée, Department of Mental Health and Psychiatry, and.
Endocrinology Unit, Medicine Department, University Hospital of Geneva, Geneva, Switzerland.
J Nerv Ment Dis. 2019 Feb;207(2):121-125. doi: 10.1097/NMD.0000000000000930.
Klinefelter syndrome (KS) 47, XXY is the most frequent chromosomal abnormality causing hypogonadism in humans. This chromosomal abnormality of number in its classical form called homogeneous (supernumerary X) is generally the result of a meiosis accident. Several studies have suggested that individuals with KS are at greater risk of developing various psychiatric disorders, including depression and schizophrenia. The diagnosis is made based on subnormal testosterone with high pituitary gonadotropins and confirmed by determining the karyotype on a blood simple. We did a literature review using an electronic search in three databases: Pubmed/MEDLINE, Google Scholar, and PsychInfo. We found that since 1989, seven case reports with KS and mental disorders with similar and different characteristics of our case illustration of a patient with KS and psychosis were published.
克兰费尔特综合征（KS）47，XXY是导致人类性腺功能减退的最常见染色体异常。这种经典形式的数量染色体异常称为同源性（额外的X染色体），通常是减数分裂意外的结果。多项研究表明，KS患者患包括抑郁症和精神分裂症在内的各种精神障碍的风险更高。诊断基于睾酮水平低于正常范围且垂体促性腺激素水平升高，并通过血液样本确定核型来确诊。我们使用电子检索在三个数据库进行了文献综述：PubMed/MEDLINE、谷歌学术和PsychInfo。我们发现，自1989年以来，已发表了七例关于KS与精神障碍的病例报告，这些病例与我们所举的一例KS伴精神病患者病例具有相似和不同的特征。
