Klinik für Innere Medizin II, Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Germany.
Klinik für Strahlentherapie und Radioonkologie, Franziskus Hospital, Kiskerstraße 26, 33615, Bielefeld, Germany.
J Cancer Res Clin Oncol. 2019 Apr;145(4):927-939. doi: 10.1007/s00432-018-02838-3. Epub 2019 Jan 23.
One important goal of any cancer therapy is to improve or maintain quality of life. In this context, mistletoe treatment is discussed to be highly controversial. The aim of this systematic review is to give an extensive overview about the current state of evidence concerning mistletoe therapy of oncologic patients regarding quality of life and side effects of cancer treatments.
In September and October 2017, Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, CINAHL and "Science Citation Index Expanded" (Web of Science) were systematically searched.
The search strategy identified 3647 articles and 28 publications with 2639 patients were finally included in this review. Mistletoe was used in bladder cancer, breast cancer, other gynecological cancers (cervical cancer, corpus uteri cancer, and ovarian cancer), colorectal cancer, other gastrointestinal cancer (gastric cancer and pancreatic cancer), glioma, head and neck cancer, lung cancer, melanoma and osteosarcoma. In nearly all studies, mistletoe was added to a conventional therapy. Regarding quality of life, 17 publications reported results. Studies with better methodological quality show less or no effects on quality of life.
With respect to quality of life or reduction of treatment-associated side effects, a thorough review of the literature does not provide any indication to prescribe mistletoe to patients with cancer.
癌症治疗的一个重要目标是提高或维持生活质量。在这方面，槲寄生治疗被认为是极具争议的。本系统评价的目的是广泛概述关于槲寄生治疗肿瘤患者的生活质量和癌症治疗副作用的当前证据状况。
2017 年 9 月至 10 月，系统检索了 Medline、Embase、Cochrane 中央对照试验注册库（CENTRAL）、PsycINFO、CINAHL 和“Science Citation Index Expanded”（Web of Science）。
该搜索策略确定了 3647 篇文章，最终有 28 篇出版物包括 2639 名患者被纳入本综述。槲寄生用于膀胱癌、乳腺癌、其他妇科癌症（宫颈癌、子宫体癌和卵巢癌）、结直肠癌、其他胃肠道癌症（胃癌和胰腺癌）、神经胶质瘤、头颈部癌症、肺癌、黑色素瘤和骨肉瘤。在几乎所有的研究中，槲寄生都被添加到常规治疗中。关于生活质量，有 17 篇出版物报告了结果。具有较好方法学质量的研究表明，对生活质量的影响较小或没有影响。
就生活质量或减少与治疗相关的副作用而言，对文献的全面回顾并没有表明可以向癌症患者开槲寄生。
