School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Centre for Brain and Mental Health Research, Hunter Medical Research Institute, Newcastle, NSW, Australia.
EMBO Rep. 2019 Feb;20(2). doi: 10.15252/embr.201947663. Epub 2019 Jan 23.
Small non-coding miRNA appear to be vital in brain development and function by organising complex patterns of gene expression. These molecules are important for the regulation of synaptically localised mRNAs that encode proteins involved in neurotransmission and behaviour. In this issue of , Lackinger [1] demonstrate that a large cluster of miRNAs, that emerged in placental mammals, functions as a repressor of social behaviour. This discovery has significant implications for our understanding of the brain, behaviour and in particular psychiatric syndromes, which have been shown to display alterations of these molecules.
小型非编码 miRNA 通过组织复杂的基因表达模式，在大脑发育和功能中似乎起着至关重要的作用。这些分子对于调节突触定位的 mRNAs 非常重要，这些 mRNAs 编码参与神经传递和行为的蛋白质。在本期的 中，Lackinger 等人[1]证明了一组在胎盘哺乳动物中出现的大型 miRNA 簇作为社会行为的抑制剂发挥作用。这一发现对我们理解大脑、行为，特别是精神疾病具有重要意义，因为已经显示这些分子发生改变与精神疾病有关。
