Mallick Bipadabhanjan, Praharaj Dibya L, Nath Preetam, Panigrahi Sarat C
Department of Gastroenterology and Hepatology, Kalinga Institute of Medical Science.
Drug Discov Ther. 2018;12(6):379-380. doi: 10.5582/ddt.2018.01069.
Apremilast is used as a systemic therapy for the treatment of psoriasis and psoriatic arthritis. This drug is considered relatively safe with a very low incidence of serious side effects. Common side effects are diarrhea, nausea, headache, nasopharyngitis, upper respiratory tract infections which are mild to moderate in severity. Diarrhea tends to occur within 2 weeks of starting treatment and resolve spontaneously within 4 weeks without dose adjustment or discontinuation of therapy. Chronic diarrhea and malnutrition due to apremilast have not been reported yet. We report a case of apremilast induced chronic diarrhea leading to malnutrition, necessitating discontinuation of therapy.
阿普米司特被用作治疗银屑病和银屑病关节炎的全身疗法。这种药物被认为相对安全，严重副作用的发生率非常低。常见副作用包括腹泻、恶心、头痛、鼻咽炎、严重程度为轻至中度的上呼吸道感染。腹泻往往在开始治疗的2周内出现，并在4周内自行缓解，无需调整剂量或停止治疗。尚未有因阿普米司特导致慢性腹泻和营养不良的报道。我们报告了一例因阿普米司特引起慢性腹泻导致营养不良，从而需要停止治疗的病例。
