Ogren S O, Fuxe K
Astra Alab AB, Research and Development, Södertälje, Sweden.
Acta Physiol Scand. 1988 May;133(1):91-5. doi: 10.1111/j.1748-1716.1988.tb08384.x.
Studies in the male rat have shown that the dopamine D-2 receptor antagonists sulpiride and eticlopride, produce a dose-dependent prevention of the hypothermia induced by the D-1/D-2 receptor agonist apomorphine and the relatively selective D-2 agonist pergolide in the rat. In contrast, the D-1 antagonist SCH 23390 (given by the s.c. and i.p. route of administration) failed to prevent the hypothermic effect induced by both DA agonists, but tended to enhance the hypothermia caused by the two DA agonists. Thus, D-2 dopamine receptors appear to play a decisive role in the mediation of the hypothermic response of apomorphine and pergolide. There may also exist an interaction between D-1 and D-2 receptors in the expression of DA-agonist-induced hypothermia.
对雄性大鼠的研究表明，多巴胺D-2受体拮抗剂舒必利和依托必利能剂量依赖性地预防大鼠中由D-1/D-2受体激动剂阿扑吗啡和相对选择性D-2激动剂培高利特诱导的体温过低。相比之下，D-1拮抗剂SCH 23390（通过皮下和腹腔注射给药途径）未能预防两种多巴胺激动剂诱导的体温过低效应，反而倾向于增强这两种多巴胺激动剂引起的体温过低。因此，D-2多巴胺受体似乎在介导阿扑吗啡和培高利特的体温过低反应中起决定性作用。在多巴胺激动剂诱导的体温过低的表达中，D-1和D-2受体之间可能也存在相互作用。
