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同步性子宫内膜样子宫内膜癌和卵巢癌具有生物学相关性：一项对22例病例的临床病理及分子（二代测序）研究

Synchronous endometrioid endometrial and ovarian carcinomas are biologically related: A clinico-pathological and molecular (next generation sequencing) study of 22 cases.

作者信息

Hájková Nikola, Tichá Ivana, Hojný Jan, Němejcová Kristýna, Bártů Michaela, Michálková Romana, Zikán Michal, Cibula David, Laco Jan, Geryk Tomáš, Méhes Gábor, Dundr Pavel

机构信息

Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12800 Prague, Czech Republic.

Department of Obstetrics and Gynecology, Bulovka Hospital, First Faculty of Medicine, Charles University, 18081 Prague, Czech Republic.

出版信息

Oncol Lett. 2019 Feb;17(2):2207-2214. doi: 10.3892/ol.2018.9855. Epub 2018 Dec 20.

DOI:10.3892/ol.2018.9855
PMID:30675285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6341770/
Abstract

The criteria for distinction between independent primary tumors and metastasis from one site to the other in synchronous endometrioid endometrial and ovarian carcinoma (SEO) has been a matter of dispute for a long time. In our study we performed a comprehensive clinico-pathological and molecular analysis of 22 cases of SEO. Based on conventional clinico-pathological criteria the cases were classified as independent primary tumors (10 cases) and metastasis from one location to the other (12 cases). All tumors were analyzed by NGS with a panel of 73 genes (219 kbp). Clonal origin was confirmed in all cases by at least one shared mutation in and . Two patients carried germline pathogenic mutation in cancer-predisposing genes or . Microsatellite instable phenotype was detected in 5/22 (22.7%) SEO, but in one case only in the endometrial tumor. In conclusion, our results showed that all 22 SEOs were clonally related, irrespectively of their clinico-pathological features. Even low grade and low stage tumors classified as independent primaries, according to the conventional morphological criteria, have a clonal origin. From the practical point of view, only the conventional morphological criteria should be used for the classification (staging) of these tumors. However, molecular profiling of these tumors may have prognostic and predictive meaning.

摘要

在同步发生的子宫内膜样子宫内膜癌和卵巢癌（SEO）中，区分独立原发性肿瘤和一处到另一处转移的标准长期以来一直存在争议。在我们的研究中，我们对22例SEO进行了全面的临床病理和分子分析。根据传统临床病理标准，这些病例被分类为独立原发性肿瘤（10例）和一处到另一处的转移（12例）。所有肿瘤均通过包含73个基因（219千碱基对）的二代测序（NGS）进行分析。通过在[具体基因1]和[具体基因2]中至少一个共享突变，在所有病例中均确认了克隆起源。两名患者在癌症易感基因[具体基因3]或[具体基因4]中携带胚系致病突变。在5/22（22.7%）的SEO中检测到微卫星不稳定表型，但仅在1例子宫内膜肿瘤中检测到。总之，我们的结果表明，所有22例SEO均为克隆相关，无论其临床病理特征如何。即使是根据传统形态学标准分类为独立原发性的低级别和低分期肿瘤，也具有克隆起源。从实际角度来看，仅应使用传统形态学标准对这些肿瘤进行分类（分期）。然而，这些肿瘤的分子谱分析可能具有预后和预测意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79cf/6341770/2723f5f6891a/ol-17-02-2207-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79cf/6341770/1784ba04bd22/ol-17-02-2207-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79cf/6341770/2723f5f6891a/ol-17-02-2207-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79cf/6341770/1784ba04bd22/ol-17-02-2207-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79cf/6341770/2723f5f6891a/ol-17-02-2207-g01.jpg

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2
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3
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5
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