Pikard Jennifer L, Oliver Dijana, Saraceno Justin, Groll Dianne
Department of Psychiatry, Queen's University, Kingston, ON, Canada.
Providence Care Mental Health Services, Kingston, ON, Canada.
SAGE Open Med Case Rep. 2019 Jan 10;7:2050313X18823101. doi: 10.1177/2050313X18823101. eCollection 2019.
Although lithium-induced dystonia has been well documented in the literature, conflicting evidence discusses whether a patient may be susceptible to adverse effects from the drug after an anoxic brain injury. More recent literature discusses that lithium may, in fact, be neuroprotective. This case report presents a 35-year-old male who, after an anoxic brain injury after a suicide attempt, developed lithium-induced dystonia with characteristic symptoms of sustained muscle contractions, repetitive movements, and postures, which was not markedly improved with benztropine or benzodiazepines. It is postulated that because this patient received a depot neuroleptic with a subsequent anoxic brain injury, he may have become more sensitive to lithium and its rare complications.
尽管锂诱导的肌张力障碍在文献中已有充分记载，但关于缺氧性脑损伤后患者是否易受该药物不良反应影响的证据存在冲突。最近的文献讨论表明，锂实际上可能具有神经保护作用。本病例报告介绍了一名35岁男性，他在自杀未遂导致缺氧性脑损伤后，出现了锂诱导的肌张力障碍，具有持续肌肉收缩、重复运动和姿势等典型症状，使用苯海索或苯二氮䓬类药物治疗后无明显改善。据推测，由于该患者在缺氧性脑损伤后接受了长效抗精神病药物治疗，他可能对锂及其罕见并发症变得更加敏感。
